银屑病患者心血管疾病风险预测

Prediction of Cardiovascular Disease Risk in Patients with Psoriasis

目的 调查银屑病患者的心血管疾病(cardiovascular disease, CVD)的风险因素并预测未来CVD的发生风险。方法纳入1067例银屑病患者(银屑病组)和1110例非银屑病体检者(对照组),分析其临床资料和风险因素。结果 与对照组比较,银屑病组与CVD病史、体重指数、高血压、糖尿病和血脂异常的相关性更强(P<0.01)。CVD在有长期银屑病病史的患者中更为常见,严重银屑病合并糖尿病的发生率更高(P<0.01)。银屑病组预测分析中,“中等风险”和“非常高风险”银屑病患者的比例较高,“老年组”的心脏年龄显著高于其实际年龄(P<0.01)。银屑病患者患CVD的风险更高,且有长期病史或严重疾病的银屑病具有更高的CVD风险。结论 银屑病患者未来CVD的发生风险和预防处理CVD并发症应引起重视。

Objective To investigate the risk factors for cardiovascular disease(CVD)and to predict the future risk of CVD in patients with psoriasis.Methods A total of 1067 psoriasis patients(psoriasis group)and 1110 physical examiners without psoriasis(control group)were included to analyze their clinical data and risk factors.Results Compared with the control group,the psoriasis group showed a stronger correlation with CVD history,body mass index,hypertension,diabetes mellitus,and dyslipidaemia(P<0.01).CVD was more common in patients with a long history of psoriasis,and the incidence of severe psoriasis with diabetes was higher(P<0.01).In the prediction analysis of psoriasis,the proportion in the“medium risk”group and the“very high risk”group were significantly higher,and the age of heart was significantly increased than their actual in the“old people”(P<0.01).The results showed that patients with psoriasis had a higher risk of CVD,and psoriasis with a long history or serious disease had a higher risk of CVD.Conclusion Attention should be paid to the future risk of CVD in patients with psoriasis and the prevention and management of CVD complications.