丁苯酞氯化钠注射液联合高频重复经颅磁刺激治疗脑梗死后肢体运动障碍的研究

Retrospective study on the treatment of limb movement disorders after cerebral infarction with sodium chloride injection of butylphthalide combined with high-frequency repeated transcranial magnetic stimulation

目的探讨丁苯酞氯化钠注射液联合高频重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)治疗脑梗死后肢体运动障碍的临床效果。方法选取2022年1月至12月湖北省第三人民医院收治的60例脑梗死患者,根据治疗方案的不同分为基础组和联合组,每组30例。基础组患者采用常规治疗方案,联合组患者采用丁苯酞氯化钠注射液联合rTMS治疗,对比两组患者治疗后的美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、日常生活活动能力(activities of daily living,ADL)评分、Fugl-Meyer运动功能评定(Fugl-Meyer motor function assessment,FMA)评分及血清100β(serum 100β,S100β)的水平。结果治疗后,联合组患者的NIHSS评分、血清S100β水平低于基础组;ADL、FMA评分高于基础组(P<0.05)。结论丁苯酞氯化钠注射液与rTMS联用治疗脑梗死后肢体运动障碍疗效显著,有助于患者神经功能的恢复,可提高患者的日常生活能力。

Objective To explore the clinical effect of sodium chloride injection of butylphthalide combined with high-frequency repeated transcranial magnetic stimulation(rTMS)in the treatment of limb movement disorders after cerebral infarction.Methods A total of 60 patients with cerebral infarction admitted to the Third People’s Hospital of Hubei Province from January to December 2022 were selected,according to the different treatment plans,the patients were divided into basic group and combination group,with 30 cases in each group.The basic group patients were treated with conventional treatment plans,while the combination group patients were treated with butylphthalide sodium chloride injection combined with rTMS.The post-treatment scores of the National Institute of Health stroke scale(NIHSS),activities of daily living(ADL),Fugl-Meyer motor function assessment(FMA),and serum 100β(S100β)were compared between the two groups.Results After treatment,the NIHSS score and serum S100βof patients in the combination group The level is lower than the basic group;The ADL and FMA scores were higher than those of the basic group(P<0.05).Conclusion The combination of sodium butylphthalide chloride injection and rTMS has a significant therapeutic effect on limb movement disorders after cerebral infarction,which can be helpful for the recovery of neurological function in patients and can improve their daily living ability.