摘要
有丝分裂是真核细胞增殖的重要环节。内体分选转运复合体是与膜剪切过程密切相关的多蛋白复合体,其功能涉及内体成熟、病毒出芽、自噬等过程,其结构和功能异常与癌症等疾病发生发展密切相关。本文总结了内体分选转运复合体在细胞有丝分裂不同阶段所发挥的作用,以及内体分选转运复合体调控有丝分裂作用在疾病方面的研究进展。
Mitosis is a key step of eukaryote proliferation.Endosomal sorting complex required for transport,a protein complex closely associated with membrane shearing,is involved in endosome maturation,virus budding,and autophagy.The structural and functional abnormalities of the complex are associated with the occurrence and progression of cancer and other diseases.In this paper,we summarized the roles of the endosomal sorting complex required for transport in different stages of mitosis and reviewed the studies about the role of the complex in regulating mitosis in diseases.
作者
高吴陆怡
杨玉
张鹏霞
商宇
GAO Wuluyi;YANG Yu;ZHANG Pengxia;SHANG Yu(Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases,School of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2024年第2期287-292,共6页
Acta Academiae Medicinae Sinicae
基金
黑龙江省省属高等学校基本科研业务费项目(2019-KYYWF-1340)
黑龙江省卫生健康委科研课题(20210202040066)
佳木斯大学博士专项科研基金启动项目(JMSUBZ2019-03)。
关键词
有丝分裂
内体分选转运复合体
纺锤体检查点
癌症
mitosis
endosomal sorting complex required for transport
spindle assembly checkpoint
cancer