重组促红细胞生成素联合布地奈德对早产儿BPD动脉血气指标、炎性反应的影响

Effect of recombinant erythropoietin combined with budesonide on arterial blood gas index,inflammatory response,ventilator application and oxygen inhalation time in premature infants with bronchopulmonary dysplasia

目的研究重组促红细胞生成素结合布地奈德对早产儿支气管肺发育不良(BPD)动脉血气指标、炎性反应、呼吸机应用及吸氧时间的影响。方法选取2021年11月至2022年10月治疗的116例早产儿,根据信封法把患儿分为观察组与对照组,对照组57例给予布地奈德进行治疗,观察组59例给予重组促红细胞生成素联合布地奈德进行治疗。比较2组患儿动脉血气指标、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)等炎性因子以及撤机时间、有创通气时间、住院时间、总吸氧时间,统计并发症发生情况。结果治疗前2组氧分压(PO_(2))、二氧化碳分压(PCO_(2))、IL-8、TNF-α、IL-4水平、治疗后颅内出血、早产儿视网膜病、感染比例比较,差异无统计学意义(P>0.05);2组治疗后PO_(2)高于治疗前且观察组患儿更高(P<0.05),治疗后2组患儿TNF-α、PCO_(2)、IL-8以及IL-4较治疗前下降且观察组更低(P<0.05);观察组患儿总吸氧时间、有创通气时间、住院时间及撤机时间较比照组短(P<0.05);治疗后观察组患儿早产儿贫血及BPD发生比例较对照组低(P<0.05)。结论重组促红细胞生成素联合布地奈德可显著改善早产儿氧合,降低炎性反应,明显缩短吸氧时间及呼吸机使用时间,降低早产儿BPD发生率。

Objective To study the effect of recombinant erythropoietin combined with budesonide on arterial blood gas index,inflammatory reaction,ventilator application and oxygen inhalation time in premature infants with bronchopulmonary dysplasia(BPD).Methods A total of 116 premature infants treated from November 2021 to October 2022 were enrolled.They were divided into observation group(n=59)and control group(n=57)according to the envelope method.Cases in the control group received budesonide,and those in the observation group received recombinant erythropoietin combined with budesonide.Arterial blood gas indexes,interleukin-8(IL-8),tumor necrosis factor(TNF-α),withdrawal time,invasive ventilation time,hospitalization time,and total oxygen inhalation time were compared.The incidence of complications was calculated.Results Before treatment,there were no significant differences in the levels of pretreatment oxygen partial pressure(PO_(2)),carbon dioxide partial pressure(PCO_(2)),and IL-8,TNF-α and IL-4,and the incidences of intracranial hemorrhage,retinopathy of premature infants,and positive rates between groups(P>0.05).After treatment,the level of PO_(2) was significantly elevated in both groups,which was significantly higher in the observation group than that of control group(P<0.05).The levels of TNF-α,PCO_(2),IL-8,IL-4 were significantly reduced in both groups,which were significantly lower in the observation group than those of control group(P<0.05).The total oxygen inhalation time,invasive ventilation time,hospitalization time,and withdrawal time in the observation group were significantly shorter than those of the control group(P<0.05).The proportions of anemia and BPD were significantly lower in the observation group than those of the control group(P<0.05).Conclusion Recombinant erythropoietin combined with budesonide can significantly improve oxygenation,reduce inflammation,shorten oxygen inhalation time and ventilator use time,and reduce the incidence of BPD in premature infants.