中医食疗联合营养治疗改善恶性肿瘤患者厌食症状

Clinical Study on Improving Cancer Anorexia in Patients with Malignant Tumor by Traditional Chinese Medicine Diet therapy Combined with Nutrition Support

目的探究中医食疗联合营养治疗改善恶性肿瘤患者厌食症状的临床研究.方法选择2022年2月至2023年2月期间在河北工程大学附属医院被确诊的106例恶性肿瘤引发的厌食患者为研究对象,并采用随机数表法分为两组,每组各53例.对照组采用标准的营养疗法,观察组则采用中医食疗和营养疗法相结合的方式.对两组患者接受干预后食欲改善情况、干预前后食欲的视觉模拟评分(Visual Analogue Scale,VAS)、安德森症状评估量表评分、体重、血前白蛋白、血白蛋白及生存质量[生存质量卡氏评分(Karnofsky,KPS)、生活质量量表评分(Quality of Life Questionnaire-Core 30,QLQ-C30)]、治疗依从性(Frankl依从量表)进行研究,并监测期间不良事件发生情况.结果进行干预前,将两组患者一般资料(性别、年龄、病程及肿瘤类型)、食欲VAS评分、安德森症状评估量表评分、体重值、血前白蛋白值、血白蛋白值、KPS评分、QLQ-C30评分进行比较,差异均无统计学意义(P>0.05).干预后,观察组总有效率为94.34%(50/53),比对照组的75.47%(40/53)明显提高(P<0.05).观察组食欲VAS评分,两组安德森症状评估量表评分均较干预前降低,且干预后观察组食欲VAS评分、安德森症状评估量表评分均低于对照组,差异有统计学意义(P<0.05).观察组患者的体重值、血前白蛋白值、血白蛋白值均较干预前有所升高,且干预后观察组体重值、血前白蛋白值、血白蛋白值均明显高于对照组(P<0.05).观察组KPS评分较干预前升高、QLQ-C30评分均较干预前降低,且干预后观察组KPS评分高于对照组、QLQ-C30评分低于对照组,差异有统计学意义(P<0.05).观察组治疗依从性明显高于对照组(P<0.05).两组干预期间均未发生呕吐、恶心、大便糖稀等不良反应.结论中医食疗联合营养治疗有利于改善恶性肿瘤癌性厌食患者食欲,提高营养状况和体重,并改善生活质量.

Objective To explore the clinical study on the improvement of cancer anorexia in patients with malignant tumor by traditional Chinese medicine(TCM)diet therapy combined with nutrition support.Meth-ods We selected 106 patients with anorexia caused by malignant tumors diagnosed in the Affiliated Hospital of He-bei University of Engineering from February 2022 to February 2023 as the study subjects,and divided them into two groups with 53 cases in each group using the random number table method.The improvement of appetite,visual analogue scale(VAS)score,Anderson symp-tom assessment scale score,weight,pre-blood albumin,blood albumin,quality of life(Karnofsky score,quality of life questionnaire-core 30 score),and treatment compliance(Frankl compliance scale)were studied in the two groups,and the occurrence of adverse events during the period was monitored.Results Before intervention,the general information(such as gender,age,course of disease and tumor type),appetite VAS score,Anderson score,body weight,prealbumin value,blood albumin value,KPS score,and QLQ-C30 score were compared between the two groups,and there was no significant differ-ence between the two groups(P>0.05).After intervention,the total effective rate of the observation group was 94.34%(50/53),which was significantly higher than that of the control group 75.47%(40/53)(P<0.05).The VAS score of the observation group and the Anderson score of both of the two groups after intervention were lower than those before the intervention.After the intervention,the VAS score and Anderson score of the observation group were lower than those of the control group after the intervention,and the difference was statistically significant(P<0.05).The body weight,pre-blood albumin value,and blood albumin value of the observation group were higher than those before intervention.The body weight,pre-blood albumin value,and blood albumin value of the observation group were sig-nificantly higher than those of the control group after intervention(P<0.05).The KPS score and QLQ-C30 score in the observation group after the intervention were higher than those before the intervention,the KPS score in the observation group was higher than that in the control group,the QLQ-C30 score of the control group was lower than that in the control group after intervention,and the difference was statistically significant(P<0.05).The treat-ment compliance of the observation group was significantly higher than that of the control group(P<0.05).There were no adverse reactions such as vomiting,nausea,or stool syrup in the two groups during the intervention peri-od.Conclusion TCM food therapy combined with nutritional support can improve the appetite of patients with malignant anorexia,improve the nutritional status and weight,and improve the quality of life.