蜂胶补充治疗对2型糖尿病合并肺部感染患者效果、炎性因子及免疫功能的影响

Effect of Propolis Supplementary Therapy on the Efficacy, Inflammatory Factors and Immune Function of Type 2 Diabetes Patients with Pulmonary Infection

目的 探究蜂胶补充治疗对2型糖尿病(T2DM)合并肺部感染的效果。方法 选择2021年3月—2022年9月收治的T2DM合并肺部感染90例,随机分为观察组、对照组各45例。对照组予以常规胰岛素、抗感染治疗,观察组在对照组基础上给予酒制蜂胶辅助治疗。比较2组临床效果及临床症状、体征改善时间及胰岛素用量,分析2组治疗前后血糖代谢及波动、血清炎性指标、免疫功能指标水平变化。结果 观察组总有效率[93.33%(42/45)]高于对照组[75.56%(34/45)](P<0.05)。观察组胰岛素用量少于对照组,血糖达标时间、体温恢复时间、肺部啰音消失时间及肺部阴影吸收时间均短于对照组(P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、C反应蛋白、降钙素原及白细胞介素-6水平低于对照组,自然杀伤细胞、CD4+/CD8+、CD4+及CD3+高于对照组(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论 蜂胶补充治疗对T2DM合并肺部感染效果较好,可快速缓解临床症状,有效调节糖代谢状态,降低炎性因子,改善机体免疫功能。

Objective To explore the effect of propolis supplementary therapy on type 2 diabetes mellitus(T2DM)complicated with pulmonary infection.Methods A total of 90 T2DM patients with pulmonary infection admitted from March 2021 to September 2022 were selected.They were randomly divided into observation group and control group,with 45 cases in each group.The control group was given conventional insulin treatment,and the observation group was given wine propolis supplementary therapy on the basis of control group.The clinical effect,time to improvement of clinical symptoms and signs,and insulin dosage of the two groups after treatment were compared,and the changes in blood glucose metabolism and fluctuations,serum inflammatory indexes and immune function indexes before and after treatment were analyzed.Results The total effective rate of observation group[93.33%(42/45)]was higher than that of control group[75.56%(34/45)](P<0.05).The dose of insulin used in observation group was less than that in control group,and the time to blood glucose compliance,body temperature recovery,lung rale disappearance and lung shadow absorption were shorter than those in control group(P<0.05).After treatment,the levels of fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),C reactive protein,procalcitonin and interleukin-6 were lower in the observation group than in the control group,while natural killer cells,CD4+/CD8+,CD4+and CD3+were higher than those in the control group(P<0.05).There was no significant different in the total incidence of adverse reactions in the two groups(P>0.05).Conclusion Propolis supplementary therapy has a good effect on patients with T2DM complicated with lung infection,which can relieve clinical symptoms rapidly,regulate glucose metabolism effectively,reduce inflammatory factors,and improve immune function.