氧化石墨烯材料在骨缺损修复中的作用研究进展

Research Progress on the Role of Graphene Oxide Materials in Bone Defect Repair

外伤、感染、肿瘤等导致的骨缺损是临床治疗难点,而目前自体或异体骨移植的治疗方法应用受限,使得骨缺损临床疗效不佳,寻找新的治疗方法迫在眉睫。氧化石墨烯是一种导电性能良好、高比表面积、力学性能优异、材料稳定,以及具有良好生物相容性和低毒性的新型材料,将其与天然材料如明胶、丝素蛋白、胶原蛋白等或者人工合成材料如聚乳酸、聚醚醚酮、生物玻璃等结合形成性能独特的骨缺损修复材料,将会为骨缺损患者带来福音。

Objective Bone defects caused by trauma,infection and tumor are difficult to treat in clinical practice.Currently,the application of autologous or allogeneic bone transplantation is limited,which leads to poor clinical effect of bone defects;therefore,it is urgent to find new treatment methods.Graphene oxide is a new material with good electrical conductivity,high specific surface area,excellent mechanical properties,good biocompatibility and low toxicity.It can be combined with natural materials such as gelatin,fibroin protein,and collagen,or artificial materials,such as polylactic acid,polyether ether ketone,and bioglass,to form a bone defect repair material with unique properties,which will benefit patients with bone defects.