β2-微球蛋白、白蛋白与碱性磷酸酶比值在睾丸精原细胞瘤中的表达及临床意义

Expression and clinical significance of β2-microglobulin and albumin to alkaline phosphatase ratio in testicular seminomas

目的探讨β2-微球蛋白(Beta 2-Microglobulin,β2-MG)、白蛋白与碱性磷酸酶比值(albumin toalkaline phosphatase ratio,AAPR)在睾丸精原细胞瘤血清中的表达水平及临床意义。方法回顾性分析2016年1月至2023年8月在右江民族医学院附属医院泌尿外科住院确诊的睾丸精原细胞瘤患者31例为病例组,选取同期在该院进行体检的健康人群39例为对照组,比较两组间β2-MG、AAPR的表达差异。应用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析血清β2-MG、AAPR在睾丸精原细胞瘤的临床诊断价值。结果β2-MG在病例组中表达水平明显高于对照组(P<0.05),AAPR在病例组中表达水平明显低于对照组(P<0.05)。β2-MG、AAPR表达水平与睾丸精原细胞瘤患者的年龄、BMI、肿瘤T分期、淋巴结转移、M分期、隐睾病史及肿瘤直径无明显相关性。ROC曲线显示β2-MG曲线下面积(area under curve,AUC)为0.759,敏感度为82.05%,特异度为61.29%;AAPR的AUC为0.788,敏感度为89.74%,特异度为64.52%;β2-MG联合AAPR的AUC为0.824,敏感度为92.31%,特异度为67.74%。结论β2-MG在睾丸精原细胞瘤患者外周血中表达明显升高,AAPR在睾丸精原细胞瘤患者中表达水平明显降低。β2-MG、AAPR对睾丸精原细胞瘤具有较高的诊断效能,且两者联合诊断效能更佳。

Objective This paper aims to investigate the expression and clinical significance of β2-microglobulin(β2-MG)and albumin to alkaline phosphatase ratio(AAPR)in testicular seminomas.Methods A retrospective analysis was conducted on 31 patients diagnosed with testicular seminomas in the urology department of the Affiliated Hospital of Youjiang Medical University For Nationalities from January 2016 to August 2023,constituting the case group.39 healthy individuals who underwent physical examinations in the same hospital during the same period were selected as the control group.The study compared the expression differences of β2-MG and AAPR between the two groups.The clinical diagnostic value of β2-MG and AAPR in testicular seminomas was analyzed using receiver operating characteristic curve(ROC).Results The expression levels of β2-MG and AAPR in patients with testicular seminomas were significantly higher than those in the control group(P<0.05).while the expression level of AAPR in the case group was significantly lower than that in the control group(P<0.05).The expression levels of β2-MG and AAPR were not significantly correlated with age,BMI,tumor T stage,lymph node metastasis,M stage,cryptorchidism history,and tumor diameter in patients with testicular seminoma.ROC curve display the area under theβ2-MG curve(AUC)is 0.759,with a sensitivity of 82.05% and specificity of 61.29%.The AUC for AAPR was 0.788,with a sensitivity of 89.74% and specificity of 64.52%.When combined,β2-MG and AAPR demonstrated an AUC of 0.824,with a sensitivity of 92.31% and specificity of 67.74%.Conclusion The expressions of β2-MG is significantly elevated in the peripheral blood of patients with testicular seminomas.while the expression level of AAPR is significantly reduced in patients with testicular seminoma.Bothβ2-MG and AAPR exhibit high diagnostic value for testicular seminoma,with heir combined use demonstrating enhanced diagnostic efficacy.