光诱导基于EDA机理构建S-芳基黄原酸酯新策略

A new strategy for the synthesis of S-arylxanthate via electron donor acceptor complex photoactivation

黄原酸酯类化合物作为药物化学、农业化学、材料化学中重要的组成部分,一直备受化学家们的关注.寻找简单、高效合成S-芳基取代黄原酸酯的方法引起了研究者广泛的关注.报道了一种可见光诱导下基于硫负离子与噻蒽盐间的EDA(电子供体受体)过程实现C-S键构建的新策略.在温和无金属的条件下,以中等至优良的收率得到了一系列S-芳基黄原酸酯,克级实验与日光实验证明了反应的应用潜力,为黄原酸酯类化合物的合成提供了一种新思路.

Xanthate esters have been attacting chemists'interest as an important component in medicinal chemistry,agricultural chemistry,and materials chemistry.However,the efficient synthesis of S-aryl-substituted xanthate esters has still faced challenges.Herein,we report a new strategy for the construction of C-S bonds based on the EDA(electron donor acceptor)process under light-induced conditions.A series of S-aryl xanthates were obtained in moderate to excellent yields under mild metal-free conditions.Gram-scale and sunlight experiments demonstrated the potential applications of the reaction,which will provide a new strategy for the synthesis of xanthate esters.