一锅多组分反应合成3-(2-(芳基乙炔)苯基)喹唑啉酮

Synthesis of 3-(2-(arylethynyl)phenyl)quinazolinones via one-pot multi-component reaction

以2-(芳基乙炔)苯胺、2-氨基芳基甲酸甲酯、原甲酸三乙酯为反应物,通过一锅多组分反应,在无需外加溶剂的条件下,以中等到良好的产率(30%~71%)实现了系列3-(2-(芳基乙炔)苯基)喹唑啉酮类化合物的合成.该类化合物可以作为新型的受体应用在自由基串联环化反应中,合成喹唑啉酮并喹啉化合物类含氮杂环.

Using 2-(arylethynyl)aniline,2-aminobenzyl formate,and ethyl trifluoromethylthioacetate as reactants,a one-pot multicomponent reaction was carried out to achieve a series of 3-(2-(arylethynyl)phenyl)quinazolinones in moderate to good yields(30%-71%)without the need for additional solvents.These compounds can be utilized as novel receptors in radical cascade cyclization reactions,leading to the synthesis of quinolino[2,1-b]quinazolinones.