血清TRAF6、activin-A、SFMC水平与子痫前期患者病情及妊娠结局的相关性

Correlation of Serum TRAF6,activin-A,SFMC Levels with Preeclampsia and the Disease and Pregnancy Outcomes

目的分析血清肿瘤坏死因子受体相关因子6(TRAF6)、糖蛋白激素-激活素A(activin-A)、可溶性纤维蛋白复合物(SFMC)水平与子痫前期患者病情及妊娠结局的相关性。方法回顾性选取2020年7月至2023年1月郑州大学第二附属医院收治的134例子痫前期患者为研究组,另选取同期健康孕检女性为对照组,根据子痫前期患者病情程度分为轻度、重度患者,所有患者均随访至分娩结束后30 d,根据本次妊娠结局是否发生不良妊娠情况将研究组分为发生、未发生患者。对比对照组和研究组、不同病情程度及不同妊娠结局患者入院时血清TRAF6、activin-A、SFMC水平,并分析其相关性,分析入院时血清各指标水平检测对子痫前期患者妊娠结局的预测价值。结果研究组入院时血清TRAF6、activin-A、SFMC水平高于对照组(P<0.05);重度患者血清TRAF6、activin-A、SFMC水平高于轻度患者(P<0.05);入院时血清TRAF6、activin-A、SFMC均与患者病情程度呈正相关(P<0.05);妊娠不良患者入院时血清TRAF6、activin-A、SFMC水平高于妊娠良好患者(P<0.05);入院时血清TRAF6、activin-A、SFMC水平联合预测子痫前期患者妊娠不良的曲线下面积(AUC)为0.748。结论血清TRAF6、activin-A、SFMC表达与子痫前期患者病情程度及预后密切相关,其三者联合检测对预测子痫前期患者妊娠不良具有较高的应用价值,可辅助临床诊疗。

Objective To analyze the correlation between serum levels of tumor necrosis factor receptor-associated factor 6(TRAF6),glycoprotein hormone-activin-A and soluble fibrin complex(SFMC)and the disease and pregnancy outcomes of preeclampsia patients.Methods A total of 134 cases of preeclampsia patients admitted to the Second Affiliated Hospital of Zhengzhou University from July 2020 to January 2023 were retrospectively selected as the study group,and healthy women during the same period were selected as the control group.According to the degree of preeclampsia,the patients were divided into mild and severe patients.All patients were followed up until 30 days after delivery.The study group was divided into patients with and without adverse pregnancy according to whether adverse pregnancy occurred in this pregnancy outcome.Serum levels of TRAF6,activin-A and SFMC were compared between the two groups,patients with different disease degrees and pregnancy outcomes at admission,and their correlation was analyzed,and the predictive value of detection of serum levels of various indicators at admission for pregnancy outcomes of preeclampsia patients was analyzed.Results The serum levels of TRAF6,activin-A and SFMC in the study group were higher than those in the control group(P<0.05).Serum levels of TRAF6,activin-A and SFMC in severe patients were higher than those in mild patients(P<0.05).Serum TRAF6,activin-A and SFMC were positively correlated with the severity of the disease(P<0.05).The serum levels of TRAF6,activin-A and SFMC in patients with adverse pregnancy were higher than those in patients with good pregnancy(P<0.05).The area under the curve(AUC)of serum TRAF6,activin-A,and SFMC combined to predict adverse pregnancy in preeclampsia patients at admission was 0.748.Conclusion The expression of serum TRAF6,activin-A and SFMC is closely related to the severity and prognosis of preeclampsia patients.The combined detection of TRAF6,activin-A and SFMC has high application value in predicting adverse pregnancy in preeclampsia patients,and can assist clinical diagnosis and treatment.