来那度胺联合硼替佐米、地塞米松治疗多发性骨髓瘤的效果及对免疫功能的影响研究

Study on the effect of Lenalidomide combined with Bortezomib and Dexamethasone in the treatment of multiple myeloma and its effect on immune function

目的 研究来那度胺联合硼替佐米、地塞米松治疗多发性骨髓瘤的效果及对免疫功能的影响。方法 选取安徽省黄山市人民医院2018年6月至2022年6月收治的80例多发性骨髓瘤患者进行研究,按照随机数字表法将其分为对照组和观察组,各40例。对照组采用硼替佐米、地塞米松治疗,观察组在对照组基础上联合来那度胺治疗,至少治疗2个疗程。比较两组临床疗效;比较两组治疗前后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平;比较两组治疗前后细胞遗传学高危发生率。结果 观察组临床疗效优于对照组(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组细胞遗传学高危发生率低于治疗前,且观察组低于对照组(P<0.05)。结论 来那度胺、硼替佐米和地塞米松联合应用于多发性骨髓瘤的临床疗效明显,可明显减轻炎症反应,改善免疫功能,促进康复,值得临床推广应用。

Objective To study the effect of Lenalidomide combined with Bortezomib and Dexamethasone in the treatment of multiple myeloma and its effect on immune function.Methods A total of 80 patients with multiple myeloma admitted to Huangshan City People’s Hospital from June 2018 to June 2022 were selected for study,they were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with Bortezomib and Dexamethasone,while observation group was treated with Lenalidomide on the basis of control group,at least treatment for two courses.The clinical efficacy of two groups was compared;the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)before and after treatment were compared between two groups;the incidence of cytogenetic risk before and after treatment was compared between two groups.Results The clinical efficacy of observation group was better than that of control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in both groups were higher than those before treatment,and those of observation group were higher than those of control group(P<0.05).After treatment,the incidence of cytogenetic risk in both groups were lower than those before treatment,and that of observation group was higher than that of control group(P<0.05).Conclusion Lenalidomide combined with Bortezomib and Dexamethasone has a significant effect in the treatment of multiple myeloma,which can effectively reduce the inflammatory reaction,improve the immune function,and promote rehabilitation,and is worthy of clinical promotion and application.