儿童川崎病与季节性病毒感染的研究进展

Research progress of Kawasaki disease and seasonal viral infection in children

川崎病又称皮肤黏膜淋巴结综合征,是感染诱发基因易感儿童的免疫性血管炎性疾病,好发于5岁以下儿童。引起川崎病的病原目前尚未明确。有关川崎病的流行病学研究表明,季节性感染病原可能是川崎病的重要病因,尤其是季节性病毒感染。本文总结近年来儿童川崎病与季节性病毒感染的相关研究,从常见呼吸道病毒与川崎病的关系、肠道病毒与川崎病的关系及病毒感染与川崎病的病理生理机制等3个方面进行综述,为川崎病病因学研究提供依据。

Kawasaki disease,also known as mucocutaneous lymphnode syndrome,is an immune vasculoinflammatory disease of infection-induced genetically susceptible children,which occurs in children under five years of age.The cause of Kawasaki disease is not yet known.Epidemiological studies on Kawasaki disease show that seasonal infectious agents may be an important cause of Kawasaki disease,especially seasonal viral infections.In this paper,the recent studies on Kawasaki disease and seasonal viral infections in children were summarized from three aspects:the relationship between common respiratory viruses and Kawasaki disease,the relationship between enterovirus and Kawasaki disease,and the pathophysiological mechanism of viral infection and Kawasaki disease,so as to provide evidence for the etiology research of Kawasaki disease.