脂蛋白相关磷脂酶A_(2)与脑小血管病患者的认知损害

Lipoprotein-associated phospholipase A_(2) and cognitive impairment in patients with cerebral small vessel disease

近年来,脑小血管病(cerebral small vessel disease,CSVD)的发病率随着人口老龄化而不断增高,且其导致的认知损害给患者及家庭带来巨大负担。作为一种新型的炎性标志物,脂蛋白相关磷脂酶A_(2)(lipoprotein-associated phospholipase A_(2),Lp-PLA_(2))通过调节循环血管损伤和神经炎症直接参与CSVD患者认知损害的发病机制,有望成为CSVD的预测指标和治疗靶点。

In recent years,the incidence of cerebral small vessel disease(CSVD)has been increasing with the aging of the population,and the cognitive impairment caused by it has brought huge burden to patients and their families.As a novel inflammatory biomarker,lipoprotein-associated phospholipase A_(2)(Lp-PLA_(2))directly participates in the pathogenesis of cognitive impairment in patients with CSVD by regulating circulatory vascular injury and neuroinflammation,and is expected to become a predictive indicator and therapeutic target for CSVD.