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心磷脂参与线粒体稳态维持和功能调节的研究进展

Update of the involvement of cardiolipin in mitochondrial homeostasis maintenance and functional regulation
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摘要 心磷脂是主要存在于线粒体内膜的一种结构独特的磷脂,在线粒体稳态和功能调节中发挥重要作用。线粒体稳态方面,心磷脂参与线粒体分裂、融合和自噬,调节线粒体的含量与结构;线粒体功能方面,心磷脂在线粒体介导的氧化磷酸化、代谢物转运和细胞凋亡等过程中发挥了独特的作用。心磷脂稳态的失衡,具体表现为含量的改变、酰基链的重塑和过氧化,可导致线粒体功能障碍并参与多种与线粒体功能障碍相关疾病的病理生理过程。本文综述了心磷脂参与线粒体稳态维持和功能调节的研究进展,并介绍了心磷脂在线粒体功能障碍相关内分泌疾病中的作用,以期对心磷脂功能研究和相关疾病的治疗起到启发作用。 Cardiolipin is a kind of phospholipid with a unique structure on the inner membrane of mitochondria.Cardiolipin plays an important role in the regulation of mitochondrial homeostasis and function,which is attributed to its special structure.In terms of mitochondrial homeostasis,cardiolipin participates in the autophagy,fission,and fusion of mitochondria,and regulates the content and structure of mitochondria.In terms of function,cardiolipin plays a unique role in mitochondrial oxidative phosphorylation,cellular metabolite transport,and cell apoptosis.Changes in cardiolipin homeostasis,manifested by alteration in content,remodeling of acyl chains,and peroxidation,can lead to mitochondrial dysfunction and participate in pathophysiological processes in a variety of diseases associated with mitochondrial dysfunction.This article reviews studies of cardiolipin in the regulation of mitochondrial homeostasis and function,and introduces the role of cardiolipin in the pathogenesis of metabolic diseases,to promote the study of cardiolipin function and the treatment of related diseases.
作者 舒惺贻 路明 章卫平 魏纯纯 Shu Xingyi;Lu Ming;Zhang Weiping;Wei Chunchun(Department of Pathophysiology,Naval Medical University,Shanghai 200433,China)
出处 《国际内分泌代谢杂志》 2024年第1期43-46,共4页 International Journal of Endocrinology and Metabolism
基金 上海市科技创新行动计划自然科学基金(21ZR1477900)。
关键词 心磷脂 线粒体稳态 线粒体功能 细胞凋亡 内分泌疾病 Cardiolipin Mitochondrial homeostasis Mitochondrial function Apoptosis Endocrine disorders
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