基于文献计量的抗生素适配体传感技术研究进展与热点分析

Progress and hot topics of antibiotic aptamer-based sensing technology:A bibliometric analysis

适配体是经体外筛选得到的短链寡核苷酸序列,能与靶标进行高亲和力和强特异性结合,以适配体为识别元件的生物传感器被广泛用于小分子传感检测研究。近年来,抗生素作为一类新兴污染物,其在环境和食品中的出现引起了人们的广泛关注。本文采用文献计量分析可视化工具VOSviewer,以Web of Science(WoS)核心数据库的文献资料为数据源,对抗生素适配体领域研究的发展过程、主要研究力量、研究热点及前沿等进行了分析。结果表明,抗生素适配体的研究发文数量不断增长,尤其是近10年呈快速增长态势;中国的累计论文发表数量最多,为378篇,占全球总发文量的57.62%,在国际合作网络中占据重要地位,而韩国、美国等国家的发文质量更高。关键词共现分析表明,抗生素适配体研究热点主要体现在“抗生素适配体筛选及性能表征”、“适配体传感器的构建及抗生素检测研究”以及“纳米材料在适配体传感检测抗生素中的应用”等3个方面。本研究提出了抗生素适配体领域未来发展方向和研究重点,有助于推进适配体生物传感技术的产业化发展。

Aptamers are short-chain oligonucleotide sequences screened in vitro,which can bind to the target with high affinity and strong specificity,and are widely used as molecular recognition elements within biosensors for the detection of small molecules.In recent years,the emergence of antibiotics as a kind of new pollutants in environment and food has attracted extensive attention of the peoples.Accordingly,the development process,main research strength,research hotspot and frontier in the field of antibiotic aptamers were analyzed by using the bibliometric analysis visualization tool VOSviewer with the Web of Science(WoS)Core Collection data as the data source.The results showed that the number of publications on antibiotic aptamers is increasing,especially in recent ten years.China has the largest cumulative number of publications(378 papers,accounting for 57.62%of the total number of published papers in the world),occupying an important position in the international cooperation network,while the United States and South Korea published higher quality papers.Keyword co-occurrence analysis showed that the research hotspots of antibiotic aptamers were mainly in three aspects:"screening and characterization of antibiotic aptamers","construction of aptamer sensors and detection of antibiotic",and"application of nanomaterials in antibiotics aptamer sensors".This study puts forward the future development direction and research focus in the field of antibiotic aptamers,which is helpful to promote the industrial development of aptamer biosensing technology.