柴芍汤治疗外科术后肠粘连临床疗效观察

Observation on clinical efficacy of Chaishao Decoction in treatment of postoperative intestinal adhesion

目的:观察柴芍汤治疗外科术后肠粘连的临床疗效。方法:纳入符合标准的80例术后肠粘连患者,随机分为中药组和对照组,每组各40例。两组患者均给予西医常规支持治疗,中药组在常规治疗基础上加服柴芍汤,治疗周期均为14 d。评价两组患者的临床疗效;治疗前后比较两组患者的中医证候总积分;比较两组患者的首次排气时间、首次自主排便时间及住院时间;治疗前后检测并比较两组患者的白介素(IL)-6、IL-10水平。结果:(1)治疗后,中药组的总有效率为90.0%,对照组为75.0%,中药组的疗效优于对照组(P<0.05)。(2)治疗后,两组患者的中医证候总积分较治疗前均显著降低(P<0.05),且中药组患者的积分显著低于对照组(P<0.05)。(3)中药组患者的首次排气时间、首次自主排便时间及住院时间均较对照组明显缩短(P<0.05)。(4)治疗后,两组患者的IL-6、IL-10水平较治疗前均降低(P<0.05),且中药组患者的IL-6、IL-10水平低于对照组(P<0.05)。结论:柴芍汤结合西医常规疗法治疗术后肠粘连,能有效缓解患者的不适症状,缩短首次排便、排气时间及住院时间,降低患者的血清炎症因子水平。

Objective:To observe the clinical efficacy of Chaishao Decoction in the treatment of postoperative intestinal adhesion.Methods:A total of 80 patients with postoperative intestinal adhesion who met the criteria were included and randomly divided into the traditional Chinese medicine group and the control group,40 cases in each group.The patients in both groups were treated with conventional supportive treatment with western medicine,and the patients in the traditional Chinese medicine group were treated with Chaishao Decoction based on above.The treatment course was 14 d.The clinical efficacy of the two groups was evaluated.Before and after treatment,the total scores of traditional Chinese medicine syndromes were compared between the two groups.The time of the first exhaust,the time of the first autonomic defecation and the time of hospital stay were compared between the two groups.Before and after treatment,the levels of interleukin(IL)-6 and IL-10 were detected and compared between the two groups.Results:①After treatment,the total effective rate was 90.0%in the traditional Chinese medicine group and 75.0%in the control group,and the efficacy of the traditional Chinese medicine group was better than that of the control group(P<0.05).②After treatment,the total scores of traditional Chinese medicine syndromes in both groups were significantly decreased compared with those before treatment(P<0.05),and the scores of the traditional Chinese medicine group were significantly lower than those of the control group(P<0.05).③The time of the first exhaust,the time of the first autonomic defecation and the time of hospital stay in the traditional Chinese medicine group were significantly shorter than those in the control group(P<0.05).④After treatment,the levels of IL-6 and IL-10 in both groups were decreased compared with those before treatment(P<0.05),and the levels of IL-6 and IL-10 in the traditional Chinese medicine group were lower than those in the control group(P<0.05).Conclusion:Chaishao Decoction combined with conventional western medicine can effectively relieve the discomfort symptoms in patients with postoperative intestinal adhesion,shorten the time of the first exhaust and defecation and the hospitalization time,and decrease the levels of serum inflammatory factors.