摘要
In the latest issue of Nature,Zhang et al.characterized a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural biology,cell biology,and bioinformatics analyses.1 In this commentary,we highlight their key findings and provide our insights into the research paradigm for further exploration of a novel transcriptional regulation mode as well as a therapeutic strategy from the structural aspects of the FOXP3 complex(Figure 1).
基金
National Key R&D Program of China(2022YFA1106400 to Z.W.and Y.L.and 2020YFA0803201 to Z.W.)
National Natural Science Foundation of China(32270886 and 32070827 to Z.W.,82273235 and 82003012 to Y.L.,and 32171216 to H.Y.)
STI2030-Major Projects(2022ZD0212600 to H.Y.).
