基于氟吡菌酰胺残留量概率分布评估膳食风险

Dietary risk assessment based on the probability distribution of fluopyram residues

基于黄瓜中氟吡菌酰胺的残留特征,全面评估了我国不同膳食消费人群的暴露风险.建立了黄瓜中氟吡菌酰胺快速、灵敏的超高效液相色谱-串联质谱痕量分析方法,定量限(LOQ)为0.001mg/kg,保留时间为2.6min.黄瓜中氟吡菌酰胺的半衰期为2.6~6.7d,属于易消解农药.最终残留水平为<LOQ~0.130mg/kg,低于我国和国际已有最大残留限量标准.通过概率性和确定性模型评估表明,氟吡菌酰胺不会对我国膳食消费人群造成不可接受的短期暴露风险(%ARfD,0.081%~2.527%),但存在不可接受的长期膳食风险(%ADI,105.740%~528.147%),其中黄瓜占比为0.325%~1.107%.此外,2~6岁儿童群体(367.156%~528.147%)的长期膳食风险显著高于其他年龄阶段人群(334.940%~105.740%)(p<0.05).综上,在后续的研究中应重点关注氟吡菌酰胺的多暴露途径和联合风险放大带来的健康暴露负效应,特别是对于弱势儿童群体.

The exposure risk of fluopyram in cucumber was comprehensively evaluated for different dietary consumption groups in China based on its residual characteristics.A rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method was developed for the determination of fluopicolide in cucumber,with limit of quantitation(LOQ)of 0.001mg/kg and retention time of 2.6 min.The half-lives of fluopyram in cucumber was 2.6~6.7d,indicated it was an easily digestible pesticide.The final levels of fluopyram was<LOQ~0.130mg/kg,which were lower than the maximum residue limit standard of China and the world.Probabilistic and deterministic models showed that fluopyram did not pose an unacceptable short-term dietary risk to Chinese dietary consumers(%ARfD,0.081%~2.527%),whereas there was an unacceptable long-term dietary risk(%ADI,105.740%~528.147%),of which cucumber accounted for 0.325%~1.107%.In addition,the long-term dietary risks of children aged 2~6 years(367.156%~528.147%)were significantly higher than that of other age groups(334.940%~105.740%)(p<0.05).In summary,we should further focus on the negative effects of fluopyram exposure under multiple exposure pathways and joint risk amplification in the follow-up study,especially for vulnerable children.