双醋瑞因调节糖脂代谢作用的研究进展

Research progress on the effect of diacerein in the regulation of glucose and lipid metabolism

双醋瑞因(diacerein,DCN)是白介素1β的抑制剂,临床已用于骨关节炎治疗,而慢性炎症被认为是肥胖症、2型糖尿病等代谢性疾病发生发展的重要病理机制,抗炎已成为改善糖脂代谢紊乱的重要策略。一系列国内外研究表明,DCN能纠正机体糖脂代谢紊乱,对代谢性疾病的治疗具有广阔的应用前景。该文对DCN调节糖脂代谢的作用机制进行总结,其作用机制涉及调节免疫和炎症反应、抗氧化应激、抑制细胞程序性死亡、调控脂肪因子分泌及增强胰岛素信号转导等,为DCN的进一步开发和运用提供依据和思路。

Diacerein(DCN),an interleukin-1β(IL-1β)inhibitor,has been clinically used for osteoarthritis.Chronic inflammation is considered as a causal factor of metabolic disorders,such as obesity and type 2 diabetes.Anti-inflammation therapy has emerged as an important strategy for improving the dysregulation of glucose and lipid metabolism.A series of domestic and international studies have shown that DCN regulates the disorders of glucose and lipid,which implies its potential application for the treatment of metabolic diseases.This paper summarized the effects and mechanisms of DCN on regulating glucose homeostasis and lipid metabolism.The mechanisms might involve the immunomodulatory and anti-inflammatory action,the effect of anti-oxidative stress,the modulation of adipokine secretion,the regulation of programmed cell death,and the enhancement of insulin signaling transduction.These findings provide perspective for further development and application of DCN.