低频重复经颅磁刺激联合抗抑郁药物治疗老年慢性失眠症伴抑郁患者的疗效及对睡眠质量的影响

The therapeutic Effect of Low-frequency Repetitive Transcranial Magnetic Stimulation Combined with Antidepressants on Elderly Patients with Chronic Insomnia and Depression,and Its Impact on Sleep Quality

目的:分析低频重复经颅磁刺激联合抗抑郁药物治疗老年慢性失眠症伴抑郁患者的疗效及对睡眠质量的影响。方法:选取2019年1月至2022年1月联勤保障部队第909医院收治的老年慢性失眠症伴抑郁患者66例作为研究对象,按照随机数字表法分为对照组和观察组,每组33例。对照组给予常规抗抑郁药物治疗干预,观察组在对照组基础上给予低频重复经颅磁刺激联合抗抑郁药物治疗。采用汉密尔顿抑郁量表(HAMD)比较2组患者干预前后抑郁状态的改善效果,采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,采用自制生命质量评价量表比较2组患者干预前后生命质量的变化,并比较2组患者的临床疗效。结果:干预后,观察组治疗有效率显著优于对照组,观察组PSQI评分、HAMD评分显著低于对照组,观察组生命质量评分显著高于对照组,差异均有统计学意义(均P<0.05)。结论:低频重复经颅磁刺激联合抗抑郁药物治疗老年慢性失眠症伴抑郁疗效显著,可有效缓解其焦虑、抑郁情绪,改善睡眠和生命质量。

Objective:To analyze the efficacy of low-frequency repetitive transcranial magnetic stimulation combined with antidepressants in the treatment of elderly patients with chronic insomnia and depression,and its impact on sleep quality.Methods:A total of 66 elderly patients with chronic insomnia and depression admitted to the 909th Hospital of the Joint Logistics Support Force from January 2019 to January 2022 were selected as the study subjects.They were randomly divided into an observation group(n=33)and a control group(n=33)using a random number table method.The control group received routine antidepressant treatment intervention,while the observation group received low-frequency repetitive transcranial magnetic stimulation combined with antidepressant treatment on the basis of the control group.The Hamilton Depression Scale(HAMD)was used to compare the improvement effect of depression status before and after intervention between two groups of patients.The Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes in sleep quality before and after intervention between the two groups of patients.The self-made Quality of Life Evaluation Scale was used to compare the changes in quality of life before and after intervention between the two groups of patients,and the clinical efficacy of the two groups of patients was also compared.Results:After intervention,the treatment effectiveness rate of the observation group was significantly better than that of the control group.The PSQI score and HAMD score of the observation group were significantly lower than those of the control group,and the quality of life score of the observation group was significantly higher than that of the control group.The differences between the two groups were statistically significant(P s<0.05).Conclusion:The combination of low-frequency repetitive transcranial magnetic stimulation and antidepressant drugs has a significant therapeutic effect on elderly chronic insomnia with depression,which can effectively alleviate anxiety and depression,and improve sleep and quality of life.