甘精胰岛素与阿卡波糖联合治疗老年糖尿病对其FBG,2 hBG,HbA1c及治疗前后的体质指数分析

Analysis of FBG,2 hBG,HbA1c and Body Mass Index before and after Treatment of Diabetes Mellitus in the Elderly by Combined Treatment of Insulin Glargine and Acarbose

目的探究老年糖尿病治疗中采用甘精胰岛素联合阿卡波糖的价值。方法选取上海市嘉定区迎园医院于2022年6月—2023年9月收治的106例糖尿病老年患者作为研究对象,按随机数表法分为对照组(53例,给予阿卡波糖治疗)、观察组(53例,给予甘精胰岛素联合阿卡波糖治疗)。比较两组临床疗效、血糖指标、体质指数(Body Mass Index,BMI)、不良反应发生情况以及胰岛功能。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组空腹血糖(Fasting Blood Glucose,FBG)、餐后2 h血糖(2 Hour Post⁃prandial Blood Glucose,2 hBG)以及糖化血红蛋白(Hemoglobin A1c,HbA1c)均低于对照组,差异有统计学意义(P均<0.05);观察组体质指数高于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05);观察组胰岛素抵抗指数(Homeostatic Model Assessment of Insulin Resis⁃tance,HOMA-IR)低于对照组,胰岛β细胞功能指数(Homeostasis Model Assessment-β,HOMA-β)高于对照组,差异有统计学意义(P均<0.05)。结论在老年糖尿病治疗中选择甘精胰岛素与阿卡波糖联合方案可降低血糖水平,改善体质指数及胰岛素功能,确保治疗有效性。

Objective To investigate the value of application insulin glargine combined with acarbose in the treatment of diabetes mellitus in the elderly.Methods A total of 106 elderly patients with diabetes admitted to Jiading Yingyuan Hospital of Shanghai from June 2022 to September 2023 were selected as the study objects,and they were divided into control group(53 cases receiving acarose treatment)and observation group(53 cases receiving insulin glargine combined with acarose treatment)according to random number table method.The clinical efficacy,blood glucose in⁃dex,body mass index(BMI),occurrence of adverse reactions and islet function were compared between the two groups.Results The total effective rate of treatment of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).Fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hBG)and hemoglobin A1c(HbA1c)in the observation group were lower than control group,and the differences were statistically significant(all P<0.05).The body mass index of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total inci⁃dence of adverse reactions between observation group and control group(P>0.05).Homeostatic model assessment of insulin resistance(HOMA-IR)of observation group was lower than control group,homeostasis model assessment-β(HOMA-β)was higher than control group,and the differences were statistically significant(both P<0.05).Conclusion In the treatment of geriatric diabetes mellitus,choosing the combination program of insulin glargine and acarbose can reduce the blood glucose level,improve the body mass index and insulin function,and ensure the effectiveness of treatment.