二甲双胍联合吡格列酮对糖尿病患者血糖水平、不良反应及效果的影响

Effects of Metformin Combined with Pioglitazone on Blood Glucose Lev⁃els,Adverse Reactions,and Outcomes in Diabetic Patients

目的分析二甲双胍联合吡格列酮治疗糖尿病的效果。方法采用目的抽样法选取柘荣县中医院内科于2022年8月—2023年8月收治的100例糖尿病患者作为研究对象,采用随机单双号法将患者分为对照组和观察组,各50例。对照组给予二甲双胍治疗,观察组联合吡格列酮,比较两组患者的临床效果、血糖控制情况、脂代谢指标以及不良反应发生率。结果观察组临床总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(P<0.05)。治疗4周后,观察组的各血糖指标水平低于对照组,差异有统计学意义(P均<0.05);观察组的血脂4项检测结果优于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论二甲双胍联合吡格列酮治疗糖尿病效果确切,且在改善糖脂代谢方面作用更加显著,同时联合用药也不会过多增加药物不良反应。

Objective To analyze the effect of metformin combined with pioglitazone in the treatment of diabetes melli⁃tus.Methods A total of 100 patients with diabetes admitted to the Internal medicine Department of Zherong County Hospital of Traditional Chinese Medicine from August 2022 to August 2023 were selected as the study objects by sam⁃pling method.The patients were divided into control group and observation group by random odd-even number method,with 50 cases in each group.The control group was given metformin treatment,and the observation group was com⁃bined with pioglitazone.The clinical effects,blood glucose control,lipid metabolism indexes and the incidence of ad⁃verse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 96.00%,higher than that of the control group(84.00%),and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the blood glucose index levels of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The results of 4 terms of serum lipids in the obser⁃vation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Metformin combined with pioglitazone is effective in the treatment of diabetes mellitus and more significant in improv⁃ing glucose and lipid metabolism,while the combination of drugs will not increase the adverse drug reactions.