抗缪勒氏管激素与性激素水平在卵巢储备功能评估中的价值

Value of Anti-mullerian Hormone and Sex Hormone Levels in the Assess⁃ment of Ovarian Reserve Function

目的分析在卵巢储备功能中抗缪勒氏管激素(Anti-mullerian Hormone,AMH)与性激素水平的评估价值。方法选取2022年3—8月宜兴市中医医院收治的100例妇科患者为研究对象,依据卵巢储备功能的不同将患者分成3组,甲组33例(卵巢储备功能正常),乙组33例(卵巢储备功能减退),丙组34例(卵巢储备功能早衰),检测所有患者AMH、卵泡刺激素(Follicle Stimulating Hormone,FSH)、黄体生成素(Luteinizing Hormone,LH)及雌二醇(Estradiol,E2)指标水平。对比3组患者上述指标检测水平、AMH分别和FSH、LH、E2联合检测的预估值。结果甲组AMH、E2高于乙组、丙组,FSH、LH低于乙组、丙组,差异有统计学意义(P均<0.05)。乙组AMH、E2高于丙组,FSH、LH低于丙组,差异有统计学意义(P均<0.05)。对乙组和丙组患者进行检测,AMH的血浆浓度时间曲线下面积(Area Under the Curve,AUC)、灵敏度、特异度大于FSH、LH、E2;AMH+FSH、AMH+LH、AMH+E2的AUC、灵敏度、特异度分别大于FSH、LH、E2。结论AMH与性激素指标可以作为临床评估卵巢储备功能参考指标,联合检测后预估价值更高。

Objective To evaluate the value of anti-mullerian hormone(AMH)and sex hormone levels in ovarian re⁃serve function.Methods A total of 100 gynecological patients admitted to Yixing Hospital of Traditional Chinese Medicine from March to August 2022 were selected as the study objects.According to different ovarian reserve func⁃tions,the patients were divided into 3 groups:Group A(33 cases)(normal ovarian reserve function),group B(33 cases)(decreased ovarian reserve function),and group C(34 cases)(premature ovarian reserve function).The levels of AMH,follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were detected in all patients.The detection levels of the above indicators and the estimated values of AMH combined with FSH,LH and E2 were compared among the 3 groups.Results AMH and E2 in group A were higher than those in groups B and C,and FSH and LH were lower than those in groups B and C,the differences were statistically significant(all P<0.05).AMH and E2 in group B were higher than those in group C,FSH and LH were lower than those in group C,and the differences were statistically significant(all P<0.05).The Area Under the Curve(AUC),sensitivity and specificity of AMH were higher than those of FSH,LH and E2.The AUC,sensitivity and specificity of AMH+FSH,AMH+LH and AMH+E2 were higher than those of FSH LH and E2.Conclusion AMH and sex hormone indexes can be used as reference in⁃dexes for clinical evaluation of ovarian reserve function,and the value of combined detection is higher.