左西替利嗪联合地氯雷他定对慢性荨麻疹患儿临床症状改善、炎性因子水平的影响

Effects of Levocetirizine Combined with Desloratadine on Improvement of Clinical Symptoms and Levels of Inflammatory Factors in Children with Chronic Urticaria

目的探究慢性荨麻疹患儿实施左西替利嗪联合地氯雷他定治疗后对其临床症状及炎性因子水平等指标的改善情况。方法选取2022年8月—2023年8月鱼台县人民医院收治的74例慢性荨麻疹患儿为研究对象,采用随机数表法将其分为参考组和研究组,各37例。参考组患儿采用地氯雷他定治疗,研究组在参考组的基础上结合左西替利嗪治疗,比较两组炎性因子水平、临床症状改善情况、治疗效果、不良反应发生率。结果研究组患儿的炎性因子水平、临床症状改善情况、治疗效果均明显优于参考组,差异有统计学意义(P均<0.05);研究组患儿不良反应总发生率为5.41%,低于参考组的18.92%,差异有统计学意义(χ^(2)=3.844,P<0.05)。结论慢性荨麻疹患儿采取左西替利嗪联合地氯雷他定治疗,其炎性因子水平、临床症状均明显改善,不良反应发生率降低,治疗效果显著。

Objective To explore the improvement of inflammatory factors and clinical symptoms in children with chronic urticaria after levocetirizine combined with desloratadine treatment.Methods A total of 74 children with chronic urticaria treated in Yutai County People's Hospital from August 2022 to August 2023 were selected as the study objects,and were divided into reference group and study group by random number table method,with 37 cases in each group.The reference group was treated with desloratadine,and the study group was treated with levocetirizine on the basis of the reference group.The levels of inflammatory factors,improvement of clinical symptoms,therapeutic effect and incidence of adverse reactions were compared between the two groups.Results The level of inflammatory factors,improvement of clinical symptoms and therapeutic effect of children in the study group were better than those in the reference group,and the differences were statistically significant(all P<0.05).The total incidence rate of ad⁃verse reactions in the study group was 5.41%,which was lower than 18.92%in the reference group,and the difference was statistically significant(χ^(2)=3.844,P<0.05).Conclusion The level of inflammatory factors and clinical symptoms in children with chronic urticaria were significantly improved by levocetirizine combined with desloratadine.The inci⁃dence rate of adverse reactions were reduced,and the therapeutic effect was obvious.