ProGRP、CEA、CA153联合检验在乳腺癌初诊者中的表达意义分析

Analysis of the Significance of the Expression of Program,CEA,and CA153 Combined Tests in First Diagnosis of Breast Cancer

目的分析血清胃泌素释放肽前体(Pro-gastrin-releasing Peptide,ProGRP)、癌胚抗原(Carcinoembryonic Antigen,CEA)以及糖类蛋白153(Carbohydrate Antigen-153,CA153)在乳腺癌初诊中的表达意义。方法选取2019年11月—2022年11月东明县人民医院检验科收治的90例乳腺癌初诊者(病理确诊为乳腺癌,为乳腺癌组)与90例良性肿瘤者(同期收治,为良性肿瘤组)作为研究对象,分别检验其血清中ProGRP、CEA、CA153指标表达水平,评估其临床表达意义、分析其疾病诊断价值。结果乳腺癌组的ProGRP、CEA及CA153指标水平均高于良性肿瘤组,差异有统计学意义(P均<0.05);与CEA、CA153指标水平相比,ProGRP指标水平的灵敏度、特异度均更高;同时3项联合检测的灵敏度、特异性以及准确度均更高。结论在乳腺癌初诊者临床诊断过程中采取ProGRP、CEA、CA153联合检验方式,临床诊断价值较高,同时ProGRP、CEA、CA153指标水平在乳腺癌患者表达上调。

Objective To analyze the significance of serum pro-gastrin-releasing peptide(ProGRP),carcinoembry⁃onic antigen(CEA),and carbohydrate antigen-153 in the initial diagnosis of breast cancer.Methods The 90 cases pri⁃mary diagnosed breast cancer patients(pathologically confirmed breast cancer,regarded as breast cancer group)and 90 cases benigh tumor patients(regarded as benigh tumor group)admitted to department of laboratory of Dongming County People's Hospital from November 2019 to November 2022 were selected as research objects.Their serum lev⁃els of ProGRP,CEA and CA153 were examined respectively to assess their clinical significance and analyze their di⁃agnostic value.Results The levels of ProGRP,CEA and CA153 in breast cancer group were higher than those in be⁃nign tumor group,and the differences were statistically significant(all P<0.05).The sensitivity and specificity of ProGRP were higher than those of CEA and CA153.At the same time,the sensitivity,specificity and accuracy of the three combined tests were higher.Conclusion In the clinical diagnosis process of primary diagnosed patients with breast cancer,ProGRP,CEA and CA153 combined assay has high clinical diagnostic value.Meanwhile,ProGRP,CEA and CA153 indicators are mainly expressed in the above levels.