新型抗精神病药布南色林个体化用药研究进展

Progress on Individualized Dosing of Blonanserin,A New Anti-Psychotic Drug

布南色林是一种新型抗精神病药,主要拮抗多巴胺D2、D3和血清素5-HT2A受体,具有独特药理学机制。可有效治疗精神分裂症,同时改善患者部分认知功能,帮助恢复社会功能。具有良好的安全性、有效性及耐受性,广泛应用于临床治疗。基于此,本文综述了布南色林的药效学、药代动力学研究、群体药代动力学、安全性及有效性、治疗药物检测、药物相互作用研究现状,基因多态性,以期为后续研究及临床个体化用药提供参考。

Blonanserin is a new type of antipsychotic,mainly antagonizing dopamine D_(2),D_(3)and serotonin 5-HT_(2A)receptors,with a unique pharmacological mechanism.It can effectively treat schizophrenia,and at the same time improve part of the cognitive function of patients and help restore social function.It has good safety,efficacy and tolerability,and is widely used in clinical treatment.Based on this,this paper reviews the pharmacodynamics,pharmacokinetic studies,population pharmacokinetics,safety,efficacy,therapeutic drug testing,drug interaction and gene polymorphism studies of blonanserin for the aim of providing reference for follow-up studies and individualized clinical treatment.