疏肝益肾汤用于子宫内膜癌根治术后的价值

The value of shugan yishen tang in postoperative endometrial cancer radical surgery

目的:分析疏肝益肾汤用于子宫内膜癌根治术患者的价值。方法:选择2020年4月—2023年1月收治的行子宫内膜癌根治术患者102例,采用随机数字表法分对照组和观察组,每组51例。对照组术后采用常规西医治疗,观察组在对照组基础上加用疏肝益肾汤治疗。比较两组患者的疼痛评分、免疫功能、生活质量及不良反应发生率。结果:治疗前,两组疼痛评分、免疫功能指标水平和肿瘤标志物水平比较,差异无统计学意义(P>0.05)。治疗后两组疼痛评分、免疫球蛋白G(IgG)和免疫球蛋白A(IgA)及肿瘤标志物水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组自然杀伤细胞(NK)、分化决定族抗原4^(+)(CD4^(+))高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后观察组生活质量总分及各项目评分均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。两组患者治疗后随访6个月,均无复发情况。结论:疏肝益肾汤用于子宫内膜癌根治术患者,可减轻术后疼痛,促进免疫功能恢复,提高患者生活质量。

Objective:To analyze the value of shugan yishen tang in treating patients with endometrial cancer undergoing radical surgery.Methods:All 102 patients with endometrial cancer who underwent radical surgery from April 2020 to January 2023 were selected as the study subjects.They were randomly divided into a control group(51 cases)and an observation group(51 cases)using a random number table method.The control group received routine western medicine treatment after surgery,while the observation group received additional treatment with shugan yishen tang.The pain scores,immune function,quality of life,and incidence of adverse reactions were compared between the two groups.Results:Before treatment,there were no significant differences in pain scores,immune function indexes and tumor markers between the two groups(P>0.05).After treatment,the scores of pain,the levels of immunoglobulin G(IgG),immunoglobulin a(IgA)and tumor markers in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of natural killer cell(NK)and clusterofdifferentiation 4^(+)(CD4^(+))in the two groups were significantly higher than those before treatment,and the levels of NK and CD4^(+)in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of NK and CD4^(+)in the natural killer cell group were significantly higher than those in the control group(P<0.05).After treatment,the total scores of quality of life and the scores of all items in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The patients in both groups were followed up for 6 months without recurrence.Conclusion:After radical surgery for endometrial cancer patients,supplementing with shugan yishen tang can alleviate postoperative pain,promote immune function recovery,and improve quality of life.