荆连四物膏对痤疮凹陷性瘢痕点阵激光后创面修复及EGF、bFGF的影响

The Effect of Jinglian Siwu Ointment on the Repair of AcneIndented Scar Wounds after Fractional CO2 Laser Treatment and Influence on EGF and bFGF

目的:观察荆连四物膏对痤疮凹陷性瘢痕点阵CO_(2)激光治疗术后创面修复的临床疗效及其对表皮细胞生长因子(EGF)和碱性成纤维细胞生长因子(bFGF)的影响。方法:选取2022年1月至2023年1月在广东省中西医结合医院诊治的80例痤疮凹陷性瘢痕患者,随机分为观察组和对照组,每组40例。两组患者均进行点阵CO_(2)激光术治疗,观察组患者用荆连四物膏外敷创面,对照组患者用湿润烧伤膏外敷创面,疗程为3个月。比较治疗后两组患者疼痛持续时间、创面完全愈合时间、视觉模拟评分法(VAS)评分、皮肤屏障功能相关指标、生活质量评分、血清EGF和bFGF水平。结果:观察组患者VAS评分低于对照组,患者疼痛持续时间、创面愈合时间均短于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者皮肤含水量高于对照组,经皮水分丢失、皮肤油脂含量均低于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者自我感知、情感功能和社会功能评分均高于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者血清EGF和bFGF水平均高于对照组,差异具有统计学意义(P<0.05)。结论:荆连四物膏外用能够促进激光术后创面愈合,可能与上调血清EGF、FbGF等生长因子水平有关。

Objective To observe the clinical efficacy of Jinglian Siwu Ointment on the repair of acne indented scar wounds after fractional CO_(2) laser treatment and its influence on epidermal growth factor(EGF)and basic fibroblast growth factor(bFGF).Methods A total of 80 patients with acne indented scars who were diagnosed and treated in from January 2022 to January 2023,admitted to Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into an observation group and a control group,with 40 cases in each group.Both groups of patients underwent fractional CO_(2) laser treatment.The observation group applied Jinglian Siwu Ointment to the wounds,while the control group applied Moist Burn Ointment to the wounds,with a treatment course of 3 months.The duration of pain,complete wound healing time,visual analogue scales(VAS)score,skin barrier function-related indicators,quality of life score,and serum levels of EGF and bFGF were compared between the two groups after treatment.Results The VAS score of the observation group was lower than that of the control group,and the duration of pain and wound healing time were shorter than those of the control group,with statistically significant differences(P<0.05).After treatment,the skin moisture content of the observation group was higher than that of the control group,while the transepidermal water loss and skin oil content were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the self-perception,emotional function,and social function scores of the observation group were higher than those of the control group,with statistically significant differences(P<0.05).After treatment,the serum levels of EGF and bFGF in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion The external use of Jinglian Siwu Ointment can promote wound healing after laser surgery,which may be related to the up-regulation of the levels of growth factors such as serum EGF and bFGF.