肾结石患者血清尿酸与白蛋白水平分析

Analysis of Serum Uric Acid and Albumin Levels in Patients with Kidney Stones

目的:探讨血清尿酸(UA)、白蛋白(ALB)与肾结石发病机制的关系。方法:将2022年1月至2023年12月就诊于广州医科大学附属清远医院的200例临床确诊肾结石患者(观察组)及200例健康对照组(对照组)纳入研究。比较两组研究对象间血清UA、ALB浓度差异,以及各组间不同性别者血清UA、ALB浓度差异。结果:(1)与对照组健康人相比,观察组患者血清UA、ALB水平明显降低,差异均具有统计学意义(P<0.05);(2)观察组患者中,男性及女性血清UA、ALB水平均明显低于对照组同性别的人,差异均具有统计学意义(P<0.05);(3)观察组和对照组之内,观察组男性与女性之间的UA水平比较,差异具有统计学意义(P<0.05);观察组男性与女性之间的ALB水平比较、对照组男性与女性之间的UA、ALB水平比较,差异均无统计学意义(P>0.05)。结论:肾结石患者血清UA、ALB水平降低,且不受患者性别影响,患者处于低水平的抗氧化状态。

Objective To investigate the relationship between serum uric acid(UA),albumin(ALB)and the pathogenesis of kidney stones.Methods The study included 200 clinically confirmed kidney stone patients(observed group)and 200 healthy controls(compared group)who visited the Affiliated Qingyuan Hospital of Guangzhou Medical University between January 2022 and December 2023.The study compared the concentrations of UA and ALB in two groups of subjects,as well as the differences in serum UA and ALB concentrations between groups of different genders.Results(1)Compared to the healthy control group,the observed group of patients had significantly lower levels of serum UA and ALB,with statistically significant differences(P<0.05).(2)In the observed group,both male and female participants had significantly lower serum UA and ALB levels compared to their counterparts in the compared group(P<0.05).(3)The comparison between males and females within the observed group and the control group showed a statistically significant difference in UA levels between males and females in the observed group(P<0.05).However,no statistically significant differences were observed in the ALB levels between males and females in the observed group or in the UA and ALB levels between males and females in the control group(P>0.05).Conclusion Serum UA and ALB levels were decreased in patients with kidney stones,and were not affected by the gender of the patient,and the patient was in a low level of antioxidant status.