脑损伤足月新生儿aEEG特点与新生儿神经功能的关系研究

Relationship between aEEG Characteristics and Neurological Function in Full-term Neonates with Brain Injury

目的:研究脑损伤足月新生儿振幅整合脑电图(aEEG)特点与新生儿神经功能的关系。方法:选取在黄河三门峡医院2020年1月至2021年12月治疗的43例脑损伤足月患儿作为观察组,另选同期出生的43例无脑损伤但存在高危因素患儿作为对照组。对两组患儿均进行aEEG检查,并使用新生儿神经行为测定(NBNA)和贝利婴幼儿发育量表(BSID)评定患儿神经功能。结果:观察组新生儿a EEG总体异常率显著高于对照组,差异具有统计学意义(P <0.05);观察组新生儿NBNA、智能发育指数(MDI)、心理运动发育指数(PDI)评分均低于对照组,差异具有统计学意义(P <0.05);轻度异常组、重度异常组新生儿的NBNA、MDI、PDI评分均低于正常组,且重度异常组的NBNA、MDI、PDI评分均低于轻度异常组,差异具有统计学意义(P <0.05);经Spearman秩相关分析,a EEG与NBNA评分呈正相关(r_(s)=0.415,P <0.05),aEEG与MDI评分呈正相关(r_(s)=0.462,P <0.05),a EEG与PDI评分呈正相关(r_(s)=0.502,P <0.05)。结论:脑损伤足月新生儿aEEG异常率更高,主要表现为振幅异常、睡眠周期缺失、出现异常放电,且与患儿神经功能密切相关。

Objective To study the relationship between amplitude integrated electroencephalogram(aEEG) characteristics and neurological function in full-term neonates with brain injury.Methods A total of 43 full-term neonates with brain injury who were treated in Yellow River Sanmenxia Hospital from January 2020 to December 2021 were selected and defined as the observation group.At the same time,43 healthy full-term neonates born during the same period were selected as the control group.Both groups received aEEG examination,and neurological function was assessed using the neonatal behavioral neurological assessment(NBNA)and the Bayley scales of infant and toddler development(BSID).Results The overall abnormal rate of aEEG in the observation group was significantly higher than that in the control group(P < 0.05).The NBNA score,mental development index(MDI) score and psychomotor development index(PDI) score in the observation group were significantly lower than those in the control group(P < 0.05).The NBNA,MDI,and PDI scores of newborns in the mild and severe abnormal groups were lower than those in the normal group,and the NBNA,MDI,and PDI scores in the severe abnormal group were lower than those in the mild abnormal group,with statistical significances(P < 0.05).According to Spearman rank correlation analysis,aEEG is positively correlated with NBNA score(r_(s) = 0.415,P < 0.05),aEEG is positively correlated with MDI score(r_(s) = 0.462,P < 0.05),and aEEG is positively correlated with PDI score(r_(s) = 0.502,P < 0.05).Conclusion The abnormal rate of aEEG in full-term newborns with brain injury is higher,mainly manifested as abnormal amplitude,loss of sleep cycle,abnormal discharge,and closely related to the neurological function of the child.