自噬调控小胶质细胞极化在缺血性脑卒中的研究进展

Research advances on the regulation of microglia polarization by autophagy in ischemic stroke

缺血性脑卒中具有发病率高、致残率高、病死率高的特点。炎症在缺血性脑卒中的发生发展中起到重要作用。活化的小胶质细胞表现出促炎(M1)和抗炎(M2)两个不同的表型,调节小胶质细胞由M1向M2型转化是临床获益关键。研究表明自噬对小胶质细胞的表型转化起到关键调控作用。如何发挥自噬的调节作用,促进小胶质细胞向M2型转化,成为减轻脑卒中后继发性脑损伤的临床研究热点,本文以此为出发点综述自噬调控小胶质细胞极化在缺血性脑卒中的研究进展,旨在为本领域基础及临床研究提供参考。

Ischemic stroke is feature by high incidence,high disability and high mortality.Inflammation plays an important role in the occurrence and development of ischemic stroke.Activated microglia exhibit two different phenotypes of proinflammatory(M1)and anti-inflammatory(M2),and regulating the transformation of microglia from M1 to M2 is the key to clinical benefit.Recent studies have shown that autophagy plays a key role in regulating phenotypic transformation of microglia.How to exert the regulatory role of autophagy and promote the transformation of microglia into M2 type has become a hotspot of clinical research in reducing secondary brain injury after stroke.This paper reviews the research progress of autophagy regulation of microglia polarization in ischemic stroke,aim‐ing to provide a reference for further clinical and basic research in this field.