2005-2023年中国猪群中猪瘟病毒流行报告:Meta分析及系统评价

Epidemic Report of Classical Swine Fever Virus in Pigs from 2005 to 2023 of China:Meta-Analysis and Systematic Review

【目的】全面了解中国猪群中猪瘟病毒(CSFV)的流行感染情况,为后期CSFV的流行病学调查提供证据。【方法】本研究在中国知网、万方、维普、PubMed、Web of Science和Science Direct国内外6种主要数据库中检索中国猪群CSFV流行情况的相关文献,检索时间范围为2005年1月1日-2023年1月1日。通过文献筛选、文献质量评分和CSFV流行率的数据提取,对文献中提取的数据利用StataMP17软件进行Meta分析和系统评价,分析CSFV的整体流行率,利用Meta回归分析和亚组分析CSFV整体流行率的异质性来源和影响因素。【结果】从6种主要数据库中共筛选出55篇CSFV流行情况的相关文献纳入本次Meta分析及系统评价,其中18篇文献被纳为高质量文献,37篇文献纳为中等质量文献。Meta分析结果表明,2005-2023年中国猪群中CSFV的整体流行率为12%(95%CI:0.09~0.15);Meta回归分析和亚组分析结果表明,文献的异质性来源不包括采样时间和猪种类(P>0.05),而影响CSFV流行率的因素包括诊断方法、季节变化、气候因素、海拔高度、纬度因素、经度因素及地区分布(P<0.05)。【结论】本研究从数据上确定了中国猪群中CSFV整体流行情况,其整体流行率不高,流行趋势为地区性的散在流行,以慢性和非典型毒株流行为主。本研究结果对掌握猪群CSFV流行的全局状况和有效防控及猪瘟(CSF)净化有一定的参考意义。

【Objective】The aim of this study was to provide more advanced evidence for a comprehensive understanding of the epidemic infection of Classical swine fever virus(CSFV)in Chinese pig herds and for the later epidemiological investigation of CSFV.【Method】In this study,the relevant literature on the prevalence of CSFV in Chinese pig herds was searched in six major databases at home and abroad,such as CNKI,Wanfang,VIP,PubMed,Web of Science and Science Direct.The search time range was from January 1,2005 to January 1,2023.Through literature screening,literature quality score and data extraction of CSFV prevalence,Meta-analysis and systematic review of the overall prevalence of CSFV were performed using StataMP17 software.Meta-regression analysis and subgroup analysis were used to analyze the heterogeneity sources and influencing factors of the overall prevalence of CSFV.【Result】A total of 55 literatures related to the prevalence of CSFV were screened from 6 major databases and included in the Meta-analysis and systematic review.Among them,18 literatures were included in the high-quality literature,and 37 literatures were included in the medium-quality literature.The results of Meta-analysis showed that the overall prevalence of CSFV in Chinese pig herds from 2005 to 2023 was 12%(95%CI:0.09-0.15).The results of Meta-regression analysis and subgroup analysis showed that the sources of heterogeneity of the literature did not include sampling time and pig species(P>0.05),while the factors affecting the prevalence of CSFV included diagnostic methods,seasonal changes,climatic factors,altitude,latitude,longitude and regional distribution(P<0.05).【Conclusion】This study determined the overall prevalence of CSFV in pigs in China from the data.The overall prevalence rate was not high,and the epidemic trend was still scattered in the region,mainly chronic and atypical strains.The results had certain reference significance for grasping the global situation of CSFV epidemic in pig herds,effective prevention and control,and purification of classical swine fever(CSF).