血清HIF-1α、HSP27、HSP70、HSP90α与肝细胞癌患者经肝动脉化疗栓塞术治疗疗效的关系研究

Study on the Relationship between Serum HIF-1α,HSP27,HSP70,HSP90αand the Efficacy of Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

目的:探讨血清缺氧诱导因子-1α(HIF-1α)、热休克蛋白(HSP)27、HSP70、HSP90α与肝细胞癌(HCC)患者经肝动脉化疗栓塞术(TACE)治疗疗效的关系。方法:选取2021年6月~2023年6月在南充市中心医院接受TACE治疗的HCC患者125例,根据TACE治疗疗效分为无效组(47例)和有效组(78例)。采用酶联免疫吸附法检测血清HIF-1α、HSP27、HSP70、HSP90α。多因素Logistic回归分析影响HCC患者TACE治疗疗效的因素,受试者工作特征(ROC)曲线分析血清HIF-1α、HSP27、HSP70、HSP90α对HCC患者TACE治疗无效的预测价值。结果:与有效组比较,无效组血清HIF-1α、HSP27、HSP70、HSP90α水平升高(P<0.05)。多因素Logistic回归分析显示,低分化、血管侵犯和HIF-1α、HSP27、HSP70、HSP90α升高为HCC患者TACE治疗无效的独立危险因素(P<0.05)。血清HIF-1α、HSP27、HSP70、HSP90α联合预测HCC患者TACE治疗无效的曲线下面积为0.958,大于血清HIF-1α、HSP27、HSP70、HSP90α单独预测的0.750、0.739、0.742、0.749。结论:血清HIF-1α、HSP27、HSP70、HSP90α升高是HCC患者TACE治疗无效的独立危险因素,血清HIF-1α、HSP27、HSP70、HSP90α联合预测HCC患者TACE治疗无效的价值较高。

Objective:To investigate the relationship between serum hypoxia-inducible factor-1α(HIF-1α),heat shock prot:ein(HSP)27,HSP70,HSP90αand the efficacy of transarterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC).Methods:125 HCC patients who were received TACE treatment in Nanchong Central Hospital from June 2021 to June 2023 were selected,and patients were divided into ineffective group(47 cases)and effective group(78 cases)according to the efficacy of TACE treatment.Serum HIF-1α,HSP27,HSP70 and HSP90αwere detected by enzyme-linked immunosorbent assay.The efficacy of TACE in HCC patients were analyzed by multivariate Logistic regression analysis.The predictive value of serum HIF-1α,HSP27,HSP70 and HSP90αfor the ineffective of TACE in HCC patients were analyzed by receiver operating characteristic(ROC)curve.Results:Compared with effective group,the levels of serum HIF-1α,HSP27,HSP70 and HSP90αin ineffective group were increased(P<0.05).Multivariate Logistic regression analysis showed that,poor differentiation,vascular invasion and increased levels of HIF-1α,HSP27,HSP70 and HSP90αwere independent risk factors for ineffective TACE treatment in HCC patients(P<0.05).The area under the curve of serum HIF-1α,HSP27,HSP70 and HSP90αcombined to predict the ineffective of TACE in HCC patients was 0.958,which was greater than the 0.750,0.739,0.742 and 0.749 predicted by serum HIF-1α,HSP27,HSP70 and HSP90αalone.Conclusion:The increase of serum HIF-1α,HSP27,HSP70 and HSP90αis an independent risk factor for the ineffective of TACE in HCC patients,the combination of serum HIF-1α,HSP27,HSP70 and HSP90αhas a high value in predicting the ineffective of TACE in HCC patients.