血清Adropin浓度与踝臂指数、肱-踝动脉脉搏波传导速度的相关性

Correlation of serum adropin concentration with ankle brachial index and brachial ankle pulse wave velocity

目的研究血清Adropin浓度与踝臂指数(ankle brachial index,ABI)、肱-踝动脉脉搏波传导速度(brachial ankle pulse wave velocity,Ba-PWV)的相关性。方法纳入2022年1月至2023年6月心内科住院治疗的患者179例,酶联免疫吸附法检测血清Adropin浓度,测量肱、踝动脉收缩压及Ba-PWV,计算ABI。根据ABI分组:ABI较低组(ABI<0.9,n=71)和ABI较高组(ABI≥0.9,n=108)。根据Ba-PWV分组:Ba-PWV较高组(Ba-PWV≥1400 cm/s,n=118),Ba-PWV较低组(Ba-PWV<1400 cm/s,n=61)。结果与ABI较高组比较,ABI较低组高血压发病率高、血清Adropin浓度低(P<0.001)。Logistic回归分析显示:血清Adropin浓度与低ABI呈负相关(偏相关系数为-0.715,P=0.027,OR=0.529,95%CI:0.342~0.987)。ROC分析:血清Adropin浓度<2998 pg/mL可预测低ABI及动脉粥样硬化(P<0.001),ROC曲线下面积:0.864;95%CI:(0.804~0.925),灵敏度:89.8%,特异性:81.7%。与Ba-PWV较低组比较,Ba-PWV较高组空腹血糖水平高、高血压病发病率高、血清Adropin浓度低(P<0.05)。Logistic回归分析:血清adropin浓度与高Ba-PWV呈负相关(偏相关系数为-0.562,P=0.002,OR=0.587,95%CI:0.398~0.837)。ROC分析:血清Adropin浓度<3019 pg/mL可预测高Ba-PWV及动脉粥样硬化(P<0.001),ROC曲线下面积:0.861;95%CI:(0.792~0.929),灵敏度:86.9%,特异性:53.4%。结论血清Adropin浓度与大动脉硬化及外周动脉粥样硬化相关。

Objective To study the correlation of serum adropin concentration with ankle brachial index(ABI)and brachial ankle pulse wave velocity(Ba-PWV).Methods A total of 179 patients visited the Department of Cardiology from January 2022 to June 2023 were enrolled in this study.Brachial systolic pressure,ankle systolic pressure and Ba-PWV were measured by Complior device.Then ABI was calculated.Serum adropin concentration was determined with an enzyme linked immunosorbent assay(ELISA)kit.According to ABI,the participants were also divided into low ABI group(ABI<0.9,n=71)and high ABI group(ABI≥0.9,n=108).The recruited subjects were further allocated to 2 groups based on Ba-PWV:high Ba-PWV group(Ba-PWV≥1400 cm/s,n=118)and low Ba-PWV group(Ba-PWV<1400 cm/s,n=61).Results Patients in low ABI group had significantly higher prevalence of hypertension(P=0.01),and significantly lower serum adropin concentration(P<0.001).Logistic regression analysis showed that serum adropin concentration was negatively correlated with low ABI(β=-0.715,P=0.027,OR=0.529,95%CI 0.342-0.987).Receiver operating characteristic(ROC)analysis showed that serum adropin concentration below 2998 pg/mL predicted low ABI and atherosclerosis(P<0.001).The area under the curve(AUC)was 0.864(95%CI 0.804,0.925),with the sensitivity of 89.8%and specificity of 81.7%.Patients in high Ba-PWV group had significantly higher fast glucose(P=0.002),significantly higher prevalence of hypertension(P=0.001),and significantly lower serum adropin concentration(P<0.001).Logistic regression analysis showed that serum adropin concentration was negatively correlated with high Ba-PWV(β=-0.562,P=0.002,OR=0.58795%CI 0.398~0.837).ROC analysis showed that serum adropin below 3019 pg/mL predicted high Ba-PWV and atherosclerosis(P<0.001).The AUC was 0.861(95%CI 0.792~0.929),with the sensitivity of 86.9%and specificity of 53.4%.Conclusion The serum adropin concentration is related with arterial stiffness and peripheral arterial atherosclerosis.