沙库巴曲缬沙坦对老年高血压患者血压控制及肝肾功能的影响

Effect of sacubitril valsartan on blood pressure control and liver and kidney function in elderly hypertensive patients

目的探究沙库巴曲缬沙坦对老年高血压患者血压控制及丙氨酸氨基转移(ALT)、肌酐(Cr)、血钾及血尿酸水平的影响。方法选取2021年5月至2022年4月温州怡宁老年医院收治的98例老年高血压患者作为研究对象,按照随机抽签法分为对照组与观察组,每组49例。对照组口服缬沙坦治疗,观察组口服沙库巴曲缬沙坦治疗,比较两组临床疗效和用药前后血压、肝肾功能(ALT、Cr)、血钾、血尿酸水平及不良反应发生率。结果观察组治疗总有效率为95.92%,高于对照组的81.63%,差异有统计学意义(P<0.05)。用药3个月后,两组舒张压、收缩压水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。用药3个月后,两组ALT、Cr水平均高于用药前,血尿酸水平均低于用药前,观察组血钾水平高于用药前,对照组血钾水平低于用药前,且观察组ALT、血钾水平均高于对照组,Cr、血尿酸水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论沙库巴曲缬沙坦对老年高血压患者的血压控制效果更理想,可改善患者肝、肾功能,降低血尿酸水平,提高血钾水平,不会增加不良反应的发生,用药安全较高,值得临床推广应用。

Objective To explore the effects of sacubitril valsartan on blood pressure control,alanine aminotransferase(ALT),creatinine(Cr),blood potassium,and blood uric acid levels in elderly hypertensive patients.Methods 98 elderly hypertensive patients admitted to Wenzhou Yining Geriatric Hospital from May 2021 to April 2022 were selected as the study subjects,and they were divided into the control group and the observation group according to the random drawing method,with 49 cases in each group.The control group received oral valsartan treatment,while the observa-tion group received oral sacubitril valsartan treatment,the clinical efficacy,blood pressure,liver and kidney function(ALT,Cr),blood potassium,blood uric acid levels before and after medication,and incidence of adverse reactions were compared between the two groups.Results The total ef-fective rate in the observation group was 95.92%,which was higher than 81.63%in the control group,and the difference was statistically significant(P<0.05).After 3 months of medication,the average diastolic and systolic blood pressure of the two groups were lower than before medication,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After 3 months of medication,the lev-els of ALT and Cr of the two groups were higher than before medication,and the levels of blood uric acid were lower than before medication,the blood potassium level in the observation group was higher than before medication,while the blood potassium level in the control group was lower than before medication,and the levels of ALT and blood potassium in the observation group were higher than those in the control group,and the levels of Cr and blood uric acid were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically signif-icant difference in the incidence of adverse reactions between the two groups.Conclusion Sacubitril valsartan has a more ideal effect on blood pres-sure control in elderly hypertensive patients,can improve liver and kidney function,reduce blood uric acid levels,increase blood potassium levels,and will not increase the occurrence of adverse reactions,the medication is relatively safe and worthy of clinical promotion and application.