盐酸羟考酮缓释片对老年晚期非小细胞肺癌癌痛患者炎症因子的影响

Effect of oxycodone hydrochloride sustained release tablets on inflammatory factors in elderly patients with cancer pain of advanced non-small cell lung cancer

目的探讨盐酸羟考酮缓释片对老年晚期非小细胞肺癌癌痛患者炎症因子的影响。方法选取2020年4月至2021年7月景德镇市第三人民医院收治的60例老年晚期非小细胞肺癌癌痛患者作为研究对象,按照随机数字表法分为对照组与观察组,每组30例。两组在常规化疗的同时服用镇痛药物,对照组服用硫酸吗啡缓释片,观察组服用盐酸羟考酮缓释片。比较两组治疗前后数字评分法(NRS)评分、血清炎症因子[白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α]水平、生命质量以及不良反应发生率。结果治疗后,两组NRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组IL-6、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组躯体功能、心理功能、社会功能和物质生活评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论对伴有癌痛的非小细胞肺癌老年患者使用盐酸羟考酮缓释片进行镇痛治疗效果显著,不仅能有效降低炎症因子水平,还可提高患者生命质量,且安全性较高。

Objective To investigate the effect of oxycodone hydrochloride sustained release tablets on inflammatory factors in elderly patients with cancer pain of advanced non-small cell lung cancer.Methods 60 elderly patients with cancer pain of advanced non-small cell lung cancer treat-ed in the Third People's Hospital of Jingdezhen from April 2020 to July 2021 were selected as the study subjects,and they were divided into the control group and the observation group according to the random number table method,with 30 cases in each group.Both groups were given analge-sic drugs along with conventional chemotherapy,the control group received morphine sulfate sustained-release tablets,and the observation group re-ceived oxycodone hydrochloride sustained-release tablets.The numeric rating scale(NRS)score,serum inflammatory factors(interleukin[IL]-6,tu-mor necrosis factor[TNF]-α)levels,quality of life before and after treatment and incidence of adverse reactions were compared between the two groups.Results After treatment,the NRS score of the two groups were lower than before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-6 and TNF-αof the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of physical function,psychological function,social function and material life of the two groups were higher than before treat-ment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The use of oxycodone hydrochloride sustained-release tablets for analgesic treatment of elderly patients with non-small cell lung cancer with cancer pain has a remarkable effect,which can not only effectively re-duce the level of inflammatory factors,but also improve the quality of life of patients with high safety.