中医药治疗特发性肺纤维化研究进展

Research Progress on Traditional Chinese Medicine in the Treatment of Idiopathic Pulmonary Fibrosis

特发性肺纤维化是原因不明的慢性进行性致纤维化间质性肺炎,主要见于中老年男性,局限于肺,临床上呈渐进性呼吸困难和肺功能恶化,组织病理学和胸部HRCT表现为特征性的寻常型间质性肺炎。特发性肺纤维化属中医学“肺痿、肺痹”范畴,中医对此病的认识历史悠久,优势明显,近年来受到越来越多的重视,通过对近5年多(2018年—至今)中医药在特发性肺纤维化的研究文献进行总结,主要从病机(“肺虚络瘀”论、“热毒滞络”论、“肺寒络凝”论、其他)、临床研究(古方、自拟方、中成药、六字诀呼吸操、热敏灸)2方面进行了综述,以期为此病的治疗提供有益的参考。

Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic interstitial pneumonia of unknown cause,mainly in middle-aged and elderly men,limited to the lung,clinically progressive dyspnea and pulmonary deterioration,histopathology and chest HRCT findings are characteristic of interstitial pneumonia of common type.Idiopathic pulmonary fibrosis belongs to the category of traditional Chinese medicine"the consumptive lung disease"and"lung bi".Traditional Chinese medicine has a long history of understanding this disease and has obvious advantages.In recent years,it has received more and more attention.Mainly from the pathogenesis of the discussion("lung deficiency collateral stasis"theory,"heat poison stagnation collateral"theory,"lung cold collaterals coagulation"theory,etc.),clinical research(ancient formula,self-designed formula,Chinese medicine,six character formula breathing exercise,heat sensitive moxibustion),clinical experience of three aspects were summarized,in order to provide useful reference for the treatment of this disease.