高分辨率超声联合血清HCY、GDF-15、GFAP对缺血性脑梗死的诊断价值研究

Diagnostic Value of High Resolution Ultrasound Combined with Serum HCY,GDF-15 and GFAP in Ischemic Cerebral Infarction

目的:探讨高分辨率超声联合血清同型半胱氨酸(HCY)、生长分化因子15(GDF-15)、神经胶质纤维酸性蛋白(GFAP)对缺血性脑梗死的诊断价值。方法:选择2021年3月-2023年3月本院收治的162例缺血性脑梗死患者作为梗死组,另选取同期138名健康体检者作为对照组,所有受试者均行高分辨率超声技术测量颈动脉内膜/中膜厚度(cIT/cMT)和桡动脉内膜/中膜厚度(rIT/rMT),所有受试者均行酶联免疫吸附试验法(ELISA)测定其血清HCY、GDF-15、GFAP水平,比较两组之间各测量参数的差异。通过绘制受试者工作特征曲线(ROC)分析高分辨率超声参数、血清HCY、GDF-15、GFAP水平对缺血性脑梗死的诊断效能。结果:梗死组cIT、rIT、血清HCY、GDF-15、GFAP水平显著高于对照组(P<0.05);而两组cMT、rMT差异无统计学意义(P>0.05)。与单独诊断相比较,高分辨率超声参数cIT、rIT联合血清HCY、GDF-15、GFAP水平对缺血性脑梗死评估的曲线下面积(AUC)、约登指数、敏感度、特异度最高。结论:高分辨率超声参数cIT、rIT联合血清HCY、GDF-15、GFAP水平对缺血性脑梗死具有更高的诊断价值,有助于指导临床对缺血性脑梗死患者的诊断。

Objective:To evaluate the diagnostic value of high resolution ultrasound combined with serum homocysteine(HCY),growth differentiation factor 15(GDF-15)and glial fibrillary acidic protein(GFAP)in ischemic cerebral infarction.Methods:162 patients with ischemic stroke admitted to our hospital from March 2021 to March 2023 were selected as the infarction group,and 138 healthy individuals during the same period were selected as the control group.All subjects underwent high-resolution ultrasound technology to measure carotid artery intima/media thickness(cIT/cMT)and radial artery intima/media thickness(rIT/rMT),and their serum HCY,GDF-15,and GFAP levels were measured using enzyme-linked immunosorbent assay(ELISA),Compared the differences in measurement parameters between two groups.Analyze the diagnostic efficacy of high-resolution ultrasound parameters,serum HCY,GDF-15,and GFAP levels for ischemic stroke by drawing receiver operating characteristic(ROC)curves.Results:The levels of cIT,rIT,serum HCY,GDF-15 and GFAP in infarction group were significantly higher than those in control group(P<0.05).There was no significant difference in cMT and rMT between the two groups(P>0.05).Compared with diagnosis alone,high resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels had the highest area under the curve(AUC),Yoden index,sensitivity and specificity in the evaluation of ischemic cerebral infarction.Conclusion:High resolution ultrasound parameters cIT and rIT combined with serum HCY,GDF-15 and GFAP levels have higher diagnostic value for ischemic cerebral infarction,which is helpful to guide the clinical diagnosis of patients with ischemic cerebral infarction.