干眼新疗法:神经刺激促进自身泪液分泌

Promoting tear production:neurostimulation for dry eye

干眼是一种常见的眼表疾病,通常由泪液分泌不足或质量不佳引起。干眼的治疗方法已有很多,但相当一部分患者治疗效果不理想,神经刺激疗法为这一难题带来了崭新的解决方案。神经刺激疗法的核心原理是通过刺激鼻部神经,借助鼻泪反射通路来促进泪液分泌。与传统干眼治疗方法相比,神经刺激疗法的独特之处在于能够促使人体自身天然泪液的分泌,而不是简单地进行成分的外源性补充。从理论上讲,这种方法有望更有效地恢复泪膜的稳定性。神经刺激促进泪液分泌是一种有前景的干眼治疗新选择,许多相关设计已成功转化,陆续完成临床试验、上市,并正在不断地改进。在实际临床应用中,神经刺激疗法能显著促进使用后即刻的泪液分泌,亦有文献报道了其长期应用能够改善干眼的症状及体征,在干眼治疗中具有很好的应用前景。建议广大眼科临床医师及研究者关注神经刺激疗法在干眼治疗中的应用和研究,未来的研究方向应更着重于探讨神经刺激疗法改善干眼症状和体征的长期作用,探索神经刺激疗法如何融入已有的干眼诊疗规范中,推广神经刺激疗法以造福更多的干眼患者。

Dry eye syndrome is a common ocular surface disorder often caused by deficient or poor-quality tear production.There are numerous therapeutic approaches to address dry eye,however,there are quite a number of patients with unsatisfactory treatment results,and neurostimulation therapy has introduced an innovative solution to this challenge.This therapy involves stimulation of the nasal nerves to activate the lacrimal reflex pathway,thereby increasing tear secretion.Unlike traditional dry eye treatments,its unique capacity is to stimulate the natural production of tears,as opposed to simply supplementing tear components.Theoretically,this method may be more effective in restoring tear film stability.Neurostimulation is a promising alternative for the management of dry eye,with several designs successfully transitioning to commercialization after clinical trials.In clinical practice,neurostimulation can significantly promote immediate tear secretion after application.In addition,some studies have reported that long-term use of neurostimulation can relieve the symptoms and signs of dry eye in some research.Ophthalmologists and ophthalmic researchers are encouraged to pay attention to the application and investigation of neurostimulation therapy in dry eye management.Future research should focus on exploring the long-term effects of neurostimulation on dry eye symptoms and signs,how it can be integrated into existing dry eye treatment protocols,and promoting neurostimulation therapy to benefit more dry eye patients.