抗菌肽在眼表感染性疾病中的应用进展

Progress in the application of antimicrobial peptides in ocular surface infectious diseases

眼表长时间暴露在外部环境下,很容易患各种眼表感染性疾病。近年来,由于病原体对抗菌药物的耐药性问题,眼表感染性疾病患者呈现治疗效果不佳、视力和生活质量严重下降等情况。目前,眼表感染性疾病已成为一个全球性的公共卫生问题,寻找一种安全、有效的治疗药物迫在眉睫。抗菌肽作为抗生素类似物,具有广谱抗菌性,能有效抵抗各种微生物的感染,包括细菌、病毒、真菌和寄生虫。抗菌肽在眼表感染性疾病的治疗中发挥着重要作用。本文就抗菌肽的结构与功能、抗菌肽在眼表感染性疾病中的作用机制、内源性抗菌肽在眼表感染中针对不同病原体的作用、外源性诱导抗菌肽对眼表感染性疾病的作用以及抗菌肽研究的最新进展等进行综述。

Due to their prolonged exposure to the external environment,eyes are susceptible to various infectious diseases of the ocular surface.In recent years,the resistance of pathogens to antimicrobial agents has led to poor treatment outcomes and significant deterioration in patients'vision and quality of life.Nowadays,ocular surface infectious diseases have become a global public health concern,necessitating the search for a safe and effective treatment.Antimicrobial peptides(AMPs),which act as antibiotic analogues,exhibit broad-spectrum antibacterial activity and are effective against a range of microbial infections,including bacteria,viruses,fungi,and parasites.AMPs play a crucial role in combating ocular surface infections.This review discusses the structure and function of AMPs,the mechanism of action of AMPs in ocular surface infections,the role of endogenous AMPs in fighting various ocular surface pathogens,the impact of exogenously induced AMPs on ocular surface infections,and recent research advances in AMPs.