基于cAMP-PKA-CREB信号通路中药防治血管性痴呆的研究进展

Research progress in traditional Chinese medicine for vascular dementia based on cAMP-PKA-CREB signaling pathway

环磷酸腺苷(cAMP)-蛋白激酶A(PKA)-cAMP响应性元件结合蛋白(CREB)是神经系统一条重要的信号途径,在血管性痴呆(Va D)的防治方面发挥重要作用。中医药是我国治疗Va D的重要手段,其主要优势在于保护脑血管、改善学习记忆与认知功能的效果显著且无明显不良反应。本文基于cAMP-PKA-CREB信号通路在脑血管病变和记忆认知功能方面的调节机制,从单味中药及中药复方的角度综述了中药防治Va D的作用机制,为今后Va D相关基础及临床研究提供理论依据。

Cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP responsive element binding protein(CREB)is an important signaling pathway in the nervous system,playing a crucial role in the prevention and treatment of vascular dementia(VaD).Traditional Chinese medicine(TCM)is an important approach in China for treating VaD.Its main advantage lies in its obvious protecting the cerebral blood vessels and improving the learning,memory,and cognitive function,without notable side effect.Based on the regulatory mechanism of the cAMP-PKA-CREB signaling pathway in cerebrovascular lesions and memory/cognitive function,this article comprehensively reviewed the mechanism of action of TCM in preventing and treating VaD with single traditional Chinese medicine or compound,to provide a theoretical basis for the future basic and clinical research on VaD.