助脉二仙汤联合镇心膏穴位贴敷治疗缓慢型心律失常患者的临床研究

Clinical Study of Zhumai Erxian Decoction Combined with Zhenxin Ointment Acupoint Application on Patients with Slow Arrhythmia

目的:探讨助脉二仙汤联合镇心膏穴位贴敷治疗缓慢型心律失常患者的临床疗效及对患者心功能、炎症因子水平的影响。方法:选取2021年2月~2023年2月期间于某院就诊的120例缓慢型心律失常患者作为研究对象,采用随机数字表法分为对照组和观察组,每组60例。对照组患者给予硫酸阿托品片治疗,观察组在对照组治疗基础上加用助脉二仙汤口服、镇心膏穴位贴敷治疗,两组均治疗4周。比较两组患者临床疗效、中医证候积分、心功能[心脏指数(CI)、每搏输出量(SV)、左室射血分数(LVEF)]、炎症因子[白介素-6(IL-6)、白介素-8(IL-8)、超敏C反应蛋白(hs-CRP)、核转录因子-κB p65(NF-κB p65)、磷酸化细胞核转录因子κB抑制蛋白α(p-IκBα)]水平及不良反应发生情况。结果:治疗后,观察组患者治疗总有效率(96.67%)高于对照组(83.33%,P<0.05);两组患者心悸胸闷、短气乏力、身寒肢冷、面色晦暗、胸痛、腰膝酸软得分均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者CI、SV、LVEF均升高(P<0.05),且观察组高于对照组(P<0.05);两组患者IL-6、IL-8、hs-CRP、NF-κB p65及p-IκBα均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者用药期间均未发生明显不良反应。结论:在硫酸阿托品片的治疗基础上联合助脉二仙汤口服、镇心膏穴位贴敷治疗缓慢型心律失常临床疗效较佳,可有效减轻患者临床症状,改善心功能,减轻炎症反应,且安全性较高。

Objective:To investigate the clinical efficacy of Zhumai Erxian decoction combined with Zhenxin ointment acupoint application in the treatment of patients with slow arrhythmia and the effects on cardiac function and inflammatory factors.Methods:A total of 120 patients with slow arrhythmia who visited a hospital from February 2021 to February 2023 were selected as the study subjects and assigned into the control group and the observation group using random number table method,with 60 cases in each group.The control group were treated with atropine sulfate tablets,and the observation group were treated with Zhumai Erxian decoction and Zhenxin ointment acupoint application in addition to the treatment in the control group.Both groups were treated for 4 weeks.The clinical efficacy,traditional Chinese medicine syndrome score,cardiac function[cardiac index(CI),stroke volume(SV),left ventricular ejection fraction(LVEF)],inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),high-sensitivity C-reactive protein(hs-CRP),nuclear factor-kappa B p65(NF-κB p65),phosphorylation inhibitor of nuclear factor kappa B alpha(p-IκBα)]and the occurrence of adverse reactions were compared between the two groups.Results:Following treatment,the overall response rate of the observation group(96.67%)was higher than that of the control group(83.33%,P<0.05).The scores of palpitation,chest tightness,shortness of breath,cold body and cold limbs,dark complexion,chest pain,waist and knee tenderness all decreased in both groups(P<0.05),with the observation group lower than the control group(P<0.05).CI,SV and LVEF in both groups increased(P<0.05),with the observation group higher than the control group(P<0.05).IL-6,IL-8,hs-CRP,NF-κB p65 and p-IκBαdecreased in the both groups(P<0.05),with the observation group lower than the control group(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusion:In addition to atropine sulfate tablets,Zhumai Erxian decoction in combination with Zhenxin ointment acupoint application in the treatment of slow arrhythmia has definite clinical efficacy,and can effectively alleviate clinical symptoms,improve heart function,reduce inflammation,with favorable safety profiles.