芪藤通痹方熏洗联合甲钴胺对DPN患者氧化应激反应及神经传导速度的影响

The Effect of Qiteng Tongbi Formula Fumigation and Washing Combined with Mecobalamin on Oxidative Stress Response and Nerve Conduction Velocity in DNP Patients

目的探讨芪藤通痹方熏洗联合甲钴胺对糖尿病周围神经病变(DNP)患者氧化应激反应、神经传导速度的影响。方法选择2021年6月至2022年12月萍乡市中医院接诊的76例DNP患者,按随机数字法分成试验组、对照组,各38例。对照组予甲钴胺治疗,试验组在此基础上予芪藤通痹方熏洗治疗,14 d后对比两组疗效,氧化应激反应及神经传导速度。结果试验组总有效率(92.11%)高于对照组(71.05%),差异有统计学意义(P<0.05)。治疗后,两组腓总神经及胫神经的运动神经传导速度和感觉神经传导速度均增加,且试验组各神经传导速度高于对照组,差异有统计学意义(P<0.05);两组总抗氧化能和超氧化物歧化酶均增高,丙二醛均降低,且试验组各氧化应激指标优于对照组,差异有统计学意义(P<0.05)。结论芪藤通痹方熏洗联合甲钴胺治疗DNP疗效确切,可减轻氧化应激损伤,增加神经传导速度。

Objective To explore the effect of qiteng tongbi formula fumigation and washing combined with mecobalamin on oxidative stress reaction and nerve conduction velocity in patients with diabetes peripheral neuropathy(DNP).Methods 76 patients with DNP admitted to Pingxiang Traditional Chinese Medicine Hospital from June 2021 to December 2022 were selected and randomly divided into an experimental group and a control group,with 38 patients in each group.Both group were treated with mecobalamin,while the experimental group was treated with qiteng tongbi formula fumigation and washing.After 14 days,the efficacy,oxidative stress response,and nerve conduction velocity of the two groups were compared.Results The total effective rate of the experimental group(92.11%)was higher than that of the control group(71.05%),with a statistical difference(P<0.05).After treatment,the motor nerve conduction velocity and sensory nerve conduction velocity of the common peroneal nerve and tibial nerve in both groups increased,and the nerve conduction velocities in the experimental group were higher than those in the control group,with statistical differences(P<0.05);both groups showed an increase in total antioxidant capacity and superoxide dismutase,while a decrease in malondialdehyde.Moreover,the experimental group had better oxidative stress indicators than the control group,with statistical differences(P<0.05).Conclusion The combination of qiteng tongbi formula fumigation and washing combined with mecobalamin has a definite therapeutic effect on DNP,which can reduce oxidative stress damage and increase nerve conduction velocity.