间苯三酚与阿托西班在先兆早产治疗中的临床效果对比分析

Comparative Analysis of Clinical Effects of Phloroglucinol and Atosiban in the Treatment of Threatened Premature Labor

目的比较分析间苯三酚与阿托西班治疗先兆早产的临床效果。方法筛选2021年1月至2023年3月上饶市妇幼保健院住院的82例先兆早产孕妇作为研究对象,随机数字表法分A组和B组,各41例。在常规治疗的基础上,A组采用间苯三酚治疗;B组采用阿托西班治疗。比较A、B两组患者用药后的药物起效时间,延长妊娠时间,临床效果,保胎成功率,性激素水平(孕酮、雌三醇),新生儿状态(体质量、头围、身长、Apgar评分)及用药不良反应。结果治疗后,A组患者的药物起效时间较B组相比更快,差异有统计学意义(P<0.05);A组延长妊娠时间较B组更短,差异有统计学意义(P<0.05);A组用药后的临床有效率与B组的临床有效率相比较低,差异有统计学意义(P<0.05);A组保胎成功率与B组相比较低,差异有统计学意义(P<0.05);A组用药后孕酮较B组低,雌三醇较B组高,差异有统计学意义(P<0.05);A组新生儿的体质量、头围、身长、Apgar评分与B组新生儿相比略低,但差异无统计学意义(P>0.05)。比较两组用药后不良反应发生率,A组略低于B组,但差异无统计学意义(P>0.05)。结论在治疗先兆早产时,阿托西班的药物起效时间相较于间苯三酚稍慢,但妊娠延长时间相较于间苯三酚更长,且阿托西班治疗先兆早产后的临床有效率、保胎成功率及改善患者性激素水平的作用与间苯三酚相比更好,故针对治疗先兆早产的患者应优先选用阿托西班。

Objective To compare the clinical effects of phloroglucinol and atosiban in the treatment of threatened premature labor.Methods A total of 82 pregnant women with threatened premature labor who were hospitalized in Shangrao Maternal and Child Health Hospital from January 2021 to March 2023 were selected as the study objects and divided into group A and group B by random number table method,with 41 cases in each group.On the basis of conventional treatment,group A was treated with phloroglucinol.Group B was treated with atosiban.The drug onset time,prolonging pregnancy time,clinical effect,success rate of fetal protection,sex hormone level(progesterone,estriol),neonatal status(body weight,head circumference,length,Apgar score)and adverse drug reactions were compared between group A and group B after medication.Results After treatment,the drug onset time in group A was faster than that in group B,the difference was statistically significant(P<0.05);the extended gestation time in group A was was shorter than that in group B,the difference was statistically significant(P<0.05).The clinical effective rate of group A was lower than that of group B,the difference was statistically significant(P<0.05).The success rate of fetal protection in group A was lower than that in group B,the difference was statistically significant(P<0.05).After treatment,progesterone in group A was lower than that in group B,estriol in group A was higher than that in group B,the difference were statistically significant(P<0.05).The body mass,head circumference,body length and Apgar score of group A were slightly lower than in group B,the difference were not statistically significant(P>0.05).The incidence of adverse reactions in group A was slightly lower than that in group B,but there was no statistical significance(P>0.05).Conclusion In the treatment of threatened preterm labor,the drug effect time of atosiban is slightly slower than that of phloroglucinol,but the pregnancy extension time is longer than that of phloroglucinol.Besides,the clinical effective rate,the success rate of fetal protection and the effect of improving the sex hormone level of patients after the treatment of threatened preterm labor are better than that of phloroglucinol.Therefore,atosiban should be preferred in the treatment of patients with threatened preterm labor.