激素性股骨头坏死发病机制的研究进展

Research progress on pathogenesis of steroid-induced osteonecrosis of the femoral head

激素诱导性股骨头坏死(steroid-induced osteonecrosis of the femoral head,SONFH)病理特征为骨细胞缺血、坏死、骨小梁断裂,股骨头塌陷。终末期SONFH临床表现为疼痛、关节功能障碍,是一类可致残的难治性骨科疾病。此病的发病机制错综复杂,常表现为多路径相互联合或交叉作用导致。本文对SONFH的发病机制及相关信号通路的研究进展进行综述,为进一步认识SONFH的发病机制及其防治研究提供帮助。

Steroid-induced osteonecrosis of the femoral head(SONFH)is a style of pathology characterized by osteocyte ischemia,ne⁃crosis and trabecular fracture and femoral head collapse.The end-stage SONFH with clinical manifestations of pain and joint dysfunction is a disabling and refractory orthopedic disease.This disorder has complex pathogenesis,often manifested by the combination or cross-action of multiple pathways.In this review,the pathogenesis and related signaling pathways of SONFH were reviewed in order to further understand the pathogenesis and prevention of SONFH.