摘要
A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using readily available diethyl bromodifluoromethanephosphonate(BrCF_(2)PO(OEt)_(2))as difluorocarbene precusor has been developed.This transformation features the efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates.A series of structurally novel and functionalized difluoromethylene-containing 1,4-thiazine derivatives were thus synthesized in good yields.
基金
Financial support from National Natural Science Foundation of China(Nos.21931013 and 22271105)
Natural Science Foundation of Fujian Province(No.2022J02009)
Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University
the Instrumental Analysis Center of Huaqiao University for analysis support
the Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University。
