Kisspeptin调控动物机体代谢的研究进展

Research Progress on the Regulation of Kisspeptin in Animal Metabolism

Kisspeptin是由KISS1基因编码的蛋白产物,是下丘脑GnRH上游的主要调控因子,其不仅在中枢系统调控动物的生殖,而且也可在外周局部影响动物配子发生。然而,最近诸多研究证实Kisspeptin除了在动物繁殖方面起到重要的作用外,还对动物能量平衡、摄食、肥胖以及代谢性疾病等方面起到重要的调节作用。本文就Kisspeptin在中枢神经系统和外周组织器官调控动物机体的代谢进行了详细论述,重点阐明Kisspeptin与外周代谢激素互作对动物机体代谢影响的最新进展,并总结分析了Kisspeptin在调控动物代谢方面所面临的诸多问题,以期充分理解Kisspeptin在调节动物代谢中发挥的作用,为防治动物及人类代谢紊乱性疾病提供新策略。

Kisspeptin,encoded by KISS1 gene,which not only regulates animal reproduction in the central system,but also affects animal gametogenesis locally in the periphery,is a major regulator upstream of hypothalamic GnRH.However,recent studies have demonstrated that Kisspeptin plays an important role in the regulation of energy balance,feeding,obesity and metabolic diseases,in addition to its important role in animal reproduction.This article provides a detailed discussion on the regulation of animal metabolism by Kisspeptin in the central nervous system and peripheral tissue organs,with a focus on elucidating the latest progress in the interaction between Kisspeptin and peripheral metabolic hormones on animal metabolism.It also summarizes and analyzes the many problems that Kisspeptin faces in regulating animal metabolism,in order to fully understand the role of Kisspeptin in regulating animal metabolism and provide new strategies for the prevention and treatment of metabolic disorders in animals and humans.