非酒精性脂肪性肝病的血清学标志物研究进展

Research progress on serological markers of non-alcoholic fatty liver disease

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患病率逐年增加,已成为严重威胁人类健康的公共卫生问题。NAFLD患者如不干预,可从单纯脂肪变性进展为非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、肝纤维化甚至是肝硬化。因此,早期诊断与治疗尤为重要。肝活检是诊断NAFLD的金标准,但因其有创、出血、高成本等局限性,限制了其在临床中的广泛应用,迫切需要灵敏、便捷的无创诊断方法来实现对NAFLD的早诊早治。本文将近年来国内外NAFLD血清学诊断方法的有关进展作一综述。

The incidence of non-alcoholic fatty liver disease(NAFLD)is increasing year by year,and it has become a serious public health problem that threatens human health.NAFLD patients can progress from simple steatosis to non-alcoholic steatohepatitis(NASH),liver fibrosis,and even cirrhosis without intervention.Therefore,early diagnosis and treatment are particularly important.Liver biopsy is the gold standard for diagnosing NAFLD,but its limitations such as invasion,bleeding,and high cost limit its widespread clinical application.There is an urgent need for sensitive and convenient non-invasive diagnostic methods to achieve early diagnosis and treatment of NAFLD.This article provides a review of the progress in serological diagnostic methods for NAFLD both domestically and internationally in recent years.