实时荧光定量核酸扩增耐甲氧西林金黄色葡萄球菌/金黄色葡萄球菌技术在耐甲氧西林金黄色葡萄球菌定植和去定植中的研究进展

Advances in Xpert MRSA/SA technology for colonisation and decolonisation of methicillin-anti staphylococcus aureus

耐甲氧西林金黄色葡萄球菌(methicillin-anti staphylococcus aureus,MRSA)是医院感染常见的致病菌之一。临床中发现许多无症状的MRSA携带者,不仅可以将菌株传播给他人,也可由于自身原因造成继发感染。采取去定植化措施可以减少MRSA定植者,从而降低内源性感染及二次传播的风险。早期识别是阻止传播和继发感染的第一步,这对于检测方法的准确性及灵敏性要求很高。Xpert MRSA/SA测定法可能是较好的一种选择,能够缩短传统方法所用的时间,并且具有较高的特异性和敏感性。区别于其他快速检测方法,Xpert MRSA/SA测定法可能更适用于MRSA的定植检测。

Methicillin-anti staphylococcus aureus(MRSA)is one of the common pathogenic bacteria in hospital infection.Many asymptomatic MRSA carriers have been found in clinical practice,which can not only transmit the strain to others,but also cause secondary infection due to their own reasons.Decolonization measures can reduce the number of MRSA colonizers,thereby reducing the risk of endogenous infection and secondary transmission.Early identification is the first step to prevent transmission and secondary infection,which requires high accuracy and sensitivity of detection methods.Xpert MRSA/SA assay(Cepheid,Sunnyvale,CA,USA)may be a better choice,which can shorten the time of traditional methods,and has high specificity and sensitivity.Unlike other rapid detection methods,the Xpert MRSA/SA assay may be more suitable for MRSA colonisation detection.